nowadays, developements in nanotechnology have leeds an increased application of this newborn technology in cancer treatment. in this study, a stabilized micelle was developed to load hpd in order to be used in photodynamic treatment of cancer in an animal model. to construct micelles, pluronic p-105 was used and stabilized to encapsulate hpd . this process includes a 24 h polymerization in whi...

Nanoparticle-Drug Conjugates To combat pancreatic cancer with a dismal prognosis, self-assembled nanoparticle-drug conjugate is synthesized in article 2203011 by Peng Huang, Shijun Wen, Jiang Yang, and co-workers. Based on chemically-modified sulfated glycosaminoglycan derivatives, (NDC) efficiently encapsulates cyclodiaryliodonium NOX inhibitor from pooled screening, enabling hyaluronidase-act...

Drug Delivery Systems The systematic review in article 2300105 by Behnam Akhavan and co-workers examines poly ethylene glycol (PEG)-based hydrogels for cancer drug delivery, emphasizing the design criteria on-demand release response to stimuli. sheds light on important factors governing controlled of anti-cancer drugs from PEG hydrogels, considering various commercial viability these critical l...

The menace of cervical cancer has reached an alarming rate. There are more than 450.000cases of cervical cancer yearly, with mortality rate of about 50%. This deadly cancer is causedby human papillomavirus (HPV), mainly subtypes 16 and 18. The pharmaceutical industryhas produced drug for combating the virus, known as SAHA (suberoylanilide hydroxamicacid). It inhibits class II HDAC Homo sapiens ...

Cancer is the second leading cause of death worldwide. Despite great efforts over many years, today cancer treatment is not very effective. The main reasons for cancer chemotherapy failure are high cytotoxicity, low response rates in solid tumors, and development of resistance. Different experimental studies have shown that drug combination using low toxicity natural compounds such as polypheno...

Objective (s): In chemotherapy for cancer treatment, the cell resistance to multiple anticancer drugs is the major clinical problem. In the present study, mesoporous silica nanoparticles (MSNs) were used as a carrier for epirubicin (EPI) in order to improve the cytotoxic efficacy of this drug against the P-glycoprotein (P-gp) overexpressing cell line. Materials and Methods: MSNs with phosphonat...

nanotechnology has slowly but steadily revolutionized the diagnosis, imaging and treatment of cancer. detecting cancer at earliest stages, locating the tumor at different areas in the body and specific delivery of the drugs to malignant cells including surgically inaccessible tumors are the core areas of medical and pharmaceutical research across the world. in this endeavour, nanodevices have e...

The application of chemotherapy in cancer treatment has been limited due to cause side effects such as toxicity against normal cells and drug resistance. In recent years, numerous studies have been focused on using natural products with chemotherapeutic drugs to enhance therapeutic efficiency and reduce cytotoxicity. On the other hand, encapsulation of drugs into nanoparticles (NPs) can improve...