نتایج جستجو برای: camp signaling pathway

تعداد نتایج: 543830  

Journal: :Current Biology 2002
Joseph A Brzostowski Cynthia Johnson Alan R Kimmel

be coupled with identical heterotrimeric G protein complexes , but, also, individual receptors may interact with and Kidney Diseases Building 50/3351 different G␣ subunits that exhibit distinct signaling capabilities. The complexity of these networks suggests National Institutes of Health Bethesda, Maryland 20892-8028 pathways for both signal integration and synergy but also for insulation and ...

Journal: :The Journal of investigative dermatology 2010
Chi-Hyun Park Youngji Moon Chung Min Shin Jin Ho Chung

Expression of matrix metalloproteinase-1 (MMP-1) is stimulated by diverse stimuli and is likely to be regulated by many signaling pathways. cAMP is known to act as a second messenger for various extracellular stimuli and to be involved in the regulation of cell proliferation, apoptosis, and inflammation. Here, we investigated the effect of cAMP on tumor necrosis factor (TNF)-alpha-induced MMP-1...

Journal: :Genetics 2013
Anu Aun Tiina Tamm Juhan Sedman

Mitochondrial metabolism is targeted by conserved signaling pathways that mediate external information to the cell. However, less is known about whether mitochondrial dysfunction interferes with signaling and thereby modulates the cellular response to environmental changes. In this study, we analyzed defective filamentous and invasive growth of the yeast Saccharomyces cerevisiae strains that ha...

2016
Isabella Maiellaro Martin J. Lohse Robert J. Kittel Davide Calebiro

The second messenger cyclic AMP (cAMP) plays an important role in synaptic plasticity. Although there is evidence for local control of synaptic transmission and plasticity, it is less clear whether a similar spatial confinement of cAMP signaling exists. Here, we suggest a possible biophysical basis for the site-specific regulation of synaptic plasticity by cAMP, a highly diffusible small molecu...

Journal: :cell journal 0

introduction: although tolerance to and dependence on opioids are characterized by excessive activity of camp pathway in some brain stem nuclei, the impact of morphine dependence on activity of camp pathway in paragigantocellularis nucleus (pgi), located in the rostral ventrolateral medulla, remains unclear. therefore, the effect of adenyl cyclase activator forskolin on spontaneous firing rate ...

Journal: :American journal of physiology. Cell physiology 2010
Martin Voss Lennart Fechner Bernd Walz Otto Baumann

We have examined the role of the Ca(2+)-dependent protein phosphatase 2B (calcineurin) in the regulation of the vacuolar H(+)-ATPase (V-ATPase) in blowfly salivary glands. In response to the neurohormone serotonin [5-hydroxytryptamine (5-HT)] and under the mediation of the cAMP/PKA signaling pathway, the secretory cells assemble and activate V-ATPase molecules at the apical membrane. We demonst...

Journal: :The Journal of Cell Biology 1994
Y He F Grinnell

Mechanical force regulates gene expression and cell proliferation in a variety of cell types, but the mechanotransducers and signaling mechanisms involved are highly speculative. We studied the fibroblast signaling mechanism that is activated when cells are switched from mechanically stressed to mechanically relaxed conditions, i.e., stress relaxation. Within 10 min after initiation of stress r...

Journal: :FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2012
Andrew C Emery Lee E Eiden

Both cAMP and ERK are necessary for neuroendocrine cell neuritogenesis, and pituitary adenylate cyclase-activating polypeptide (PACAP) activates each. It is important to know whether cAMP and ERK are arranged in a novel, linear pathway or in two parallel pathways using known signaling mechanisms. Native cellular responses [cAMP elevation, ERK phosphorylation, cAMP responsive element binding (CR...

Journal: :Eukaryotic cell 2007
Yong-Sun Bahn Matthew Molenda Janet F Staab Courtney A Lyman Laura J Gordon Paula Sundstrom

Candida albicans is an opportunistic human fungal pathogen that causes systemic candidiasis as well as superficial mucosal candidiasis. In response to the host environment, C. albicans transitions between yeast and hyphal forms. In particular, hyphal growth is important in facilitating adhesion and invasion of host tissues, concomitant with the expression of various hypha-specific virulence fac...

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