Abstract Background Many LGBTQ youth experience rejection and discrimination in their families schools, the range of interventions for improving resilience well-being is limited. We developed piloted an LGBTQ-youth-focused intervention to build promote health equity, called Pride Camp, urban environment Midwest. Methods Using a mixed-method approach we examined impact Camp on other measures amo...

Cutaneous squamous cell carcinoma (cSCC) is a common cancer, caused by mutagenesis from excess ultraviolet radiation (UVR) or other types of oxidative stress. These stressors also upregulate production key innate immune element, cathelicidin antimicrobial peptide (CAMP), via endoplasmic reticulum (ER) stress-initiated, sphingosine-1-phosphate (S1P) signaling. While CAMP has beneficial activitie...

To improve understanding of acne we evaluated host cell networks in the pilosebaceous unit and variables associated with C. acnes that promote skin inflammation. Single-cell RNA sequencing uncovered unsuspected activation specific dermal fibroblast subsets both human mice challenged by acnes. This transcriptional response was characterized initiation fat differentiation expression cathelicidin ...

Lithium (Li), a glycogen synthase kinase-3β (GSK-3β) inhibitor, has used to attenuate thecannabinoid-induced dependence/withdrawal signs, but molecular mechanisms related to this areunclear. Recent studies indicate the involvement of upstream extracellular signal kinase1/2 (ERK1/2)and downstream GSK-3β pathways in the development of cannabinoid-induced dependence. Thisis mediated through cannab...

Lithium (Li), a glycogen synthase kinase-3β (GSK-3β) inhibitor, has used to attenuate thecannabinoid-induced dependence/withdrawal signs, but molecular mechanisms related to this areunclear. Recent studies indicate the involvement of upstream extracellular signal kinase1/2 (ERK1/2)and downstream GSK-3β pathways in the development of cannabinoid-induced dependence. Thisis mediated through cannab...

Background and Purpose: Globally, dermatophytes are the most common filamentous group of fungi causing cutaneous mycoses. Dermatophytes were shown to secrete a multitude of enzymes that play a role in their pathogenesis. There is limited data on co-hemolytic (CAMP-like) effect of different bacterial species on dermatophyte species. In this study, we sought to the evaluate exoenzyme activity an...

This paper offers new insights into the role of firms versus individuals in driving technology directions, and the extent to which human capital may be lost during industrial shifts. We explore in particular whether (1) due to different offshore production economics, firms who move manufacturing offshore slow U.S.-based R&D activities in an emerging technology and (2) the inventors originally w...

Background: Phosphodiesterase 3A (PDE3A) and phosphodiesterase 3B (PDE3B) play a critical role in the regulation of intracellular level of adenosine 3´,5´-cyclic monophosphate (cyclic AMP, cAMP) and guanosine 3´,5´-cyclic monophosphate (cyclic GMP, cGMP). Subsequently PDE3 inhibitors have shown to relax vascular and inhibit platelet aggregation in cardiovascular disease. Objectives: In th...