The main objective is to study the inhibitor effect of hydroalcoholic extract of Achyranthes indica Linn. on the crystallization of calcium oxalate in synthetic urine. Our study of the calcium oxalate crystallization is based on change in turbidity followed at 620nm by means of a spectrophotometer. The calcium oxalate formation is induced by the addition of 0.01M sodium oxalate solutions in syn...

During the past six years, we have treated eight patients with cystic fibrosis (CF) for nephrolithiasis. In seven patients, the stones were comprised of calcium oxalate. Another six patients had calcium oxalate crystalluria. In our CF population of 140 patients, this represents a cumulative incidence of calcium oxalate nephrolithiasis of 5.7 percent and an additional 4.2 percent incidence of cr...

The anti-nephrolithiasis effect of Xue Niao An (XNA) capsules is explored by analyzing urine metabolic profiles in mouse models, with ultra-high performance liquid chromatography quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF/MS). An animal model of calcium oxalate crystal renal deposition was established in mice by intra-abdominal injection of glyoxylate. Then, treatment with XNA by i...

The experiments presented in this paper brought out the following facts. Intramuscular injections of sodium oxalate into rabbits in doses of 0.18 and 0.2 gm. proved to be invariably fatal, death generally occurring in a comparatively short time. The symptoms consisted in excitation and tonic and clonic convulsions of diminishing strength if death was delayed. Some animals succumbed in the first...

The location of calcium in muscle fibers is of interest, since the contraction-relaxation cycle is controlled by intracellular movements of this ion (Ebashi and Lipmann, 1962 ; Hasselbach and Makinose, 1963 ; Weber et al., 1963; Podolsky and Costantin, 1964). Treatment of the cell with oxalate produces electron-opaque deposits localized in the terminal sacs of the sarcoplasmic reticulum (SR) th...

About 12% of men and 5% of women of Western European descent develop at least one urinary stone during their lifetime. The incidence is somewhat less in individuals of sub-Saharan African or Asian descent, although there is a high incidence in the Middle Eastern countries. Calcium oxalate is a major constituent of about 70% of these stones. They are of multifactorial origin, with both genetic a...

Calcium oxalate monohydrate crystals are responsible for the kidney injury associated with exposure to ethylene glycol or severe hyperoxaluria. Current treatment strategies target the formation of calcium oxalate but not its interaction with kidney tissue. Because aluminum citrate blocks calcium oxalate binding and toxicity in human kidney cells, it may provide a different therapeutic approach ...

1. A low urinary magnesium was induced in normal volunteer subjects by giving cellulose phosphate; magnesium was added in vitro to yield urine samples of normal and high magnesium concentrations. 2. After rapid evaporation of these urine samples at pH 5.3 to standard osmolality the calcium oxalate crystals were measured by microscopy and isotopic methods. 3. There was a clear inverse correlatio...