The activation of Ca-dependent K+ current, Ic, was studied in macropatches on the cell bodies of molluscan neurons. When a depolarizing voltage-clamp pulse was applied repeatedly, Ic facilitated in a manner that resembled the facilitation of synaptic transmitter release. Facilitation was characterized by an increase in Ic amplitude, a progressive increase in instantaneous outward current, and a...

Dear Sir: Recently Lee et al. (1978) and Akaike et al. (1978) have published in this Journa l two very interest ing papers , repor t ing elegant exper iments with the internally per fused nerve cell bodies. We are especially happy with the success of these authors: the idea o f how simple it is to substitute the cytoplasm of the cell body by artificial saline has once more appeared to be frui t...

Dear Sir: Recently Lee et al. (1978) and Akaike et al. (1978) have published in this Journa l two very interest ing papers , repor t ing elegant exper iments with the internally per fused nerve cell bodies. We are especially happy with the success of these authors: the idea o f how simple it is to substitute the cytoplasm of the cell body by artificial saline has once more appeared to be frui t...

The coronary artery calcium score plays an Important role In cardiovascular risk stratification, showing a significant association with the medium- or long-term occurrence of major cardiovascular events. Here, we discuss the following: protocols for the acquisition and quantification of the coronary artery calcium score by multidetector computed tomography; the role of the coronary artery calci...