Cornelia Isabella Bargmann studied the relationship between genes [4], neural circuits, and behavior in the roundworm Caenorhabditis elegans [5] (C. elegans) during the twentieth and twenty-first centuries in the US. Bargmann?s research focused on how the sense of smell (olfaction) in the nematode word Caenorhabditis elegans [6]. She provided a model to study how neural circuits develop and fun...

Scientific research experiences are beneficial to students allowing them gain laboratory and problem-solving skills, as well foundational skills in a team-based setting. We designed module provide guided experience stimulate curiosity, introduce experimental techniques, with needed for higher levels of inquiry. In this module, learn about RNA interference (RNAi) codon optimization using the org...

Dopamine is an ancient signaling molecule. It is responsible for maintaining the adaptability of behavioral outputs and is found across taxa. The following is a summary of the role of dopamine and the mechanisms of its function and dysfunction. We discuss our recent findings on dopaminergic control of behaviors in C. elegans and discuss its potential implications for work in the fields of C. el...

Collective epithelial cell migration requires the maintenance of cell-cell junctions while enabling the generation of actin-rich protrusions at the leading edge of migrating cells. Ventral enclosure of Caenorhabditis elegans embryos depends on the collective migration of anterior-positioned leading hypodermal cells towards the ventral midline where they form new junctions with their contralater...

The nematode Caenorhabditis elegans is an excellent model organism for a systems-level understanding of neural circuits and behavior. Advances in the quantitative analyses of behavior and neuronal activity, and the development of new technologies to precisely control and monitor the workings of interconnected circuits, now allow investigations into the molecular, cellular, and systems-level str...

Protein family Biochemical function Representative Proteins H. sapiens D. melanogaster C. elegans A. thaliana S. cerevisiae S. pombe

Stearic acid represents one of the most abundant fatty acids in Western diet and profoundly regulates health diseases animals human beings. We previously showed that stearic supplementation promoted development terrestrial model nematode Caenorhabditis elegans chemically defined CeMM food environment. However, whether other nematodes remains unknown. Here, we found dietary with could promote ma...

Caffeine is a widely used psychoactive substance. Studies have shown that caffeine may play a protective role in aging-associated disorders. However, the mechanisms by which caffeine modulates aging are not yet clear. In this study, we have shown that caffeine increases Caenorhabditis elegans lifespan, delays its larval development, reduces reproduction and body length. These phenotypes were pa...

Genes regulating Caenorhabditis elegans insulin/IGF signaling (IIS) have largely been identified on the basis of their involvement in dauer development or longevity. A third IIS phenotype is the first larval stage (L1) diapause, which is also influenced by asna-1, a regulator of DAF-28/insulin secretion. We reasoned that new regulators of IIS strength might be identified in screens based on the...

Remediation of Bacillus anthracis-contaminated soil is challenging and approaches to reduce overall spore levels in environmentally contaminated soil or after intentional release of the infectious disease agent in a safe, low-cost manner are needed. B. anthracis spores are highly resistant to biocides, but once germinated they become susceptible to traditional biocides or potentially even natur...