The UPF0016 family is a group of uncharacterized membrane proteins, well conserved through evolution and defined by the presence of one or two copies of an E-Φ-G-D-(KR)-(ST) consensus motif. Our previous results have shown that two members of this family, the human TMEM165 and the budding yeast Gdt1p, are functionally related and might form a new group of cation/Ca2+ exchangers. Most members of...

Considerable evidence suggests that the neurotransmitter gamma-aminobutyric acid (GABA)-ergic system and pedunculopontine tegmentum (PPT) in the brain stem are critically involved in the regulation of rapid-eye-movement (REM) sleep. GABA and its various receptors are normally present in the PPT cholinergic cell compartment. The aim of this study was to identify the role of GABA and its receptor...

Alix, Philippe, Francoise Grolleau, and Bernard Hue. Ca /Calmodulin-dependent protein kinase regulates GABA-activated chloride current in cockroach dorsal unpaired median (DUM) neurons. J Neurophysiol 87: 2972–2982, 2002; 10.1152/jn.00631.2001. We studied -aminobutyric acid (GABA)-mediated currents in short-term cultured dorsal unpaired median (DUM) neurons of cockroach Periplaneta americana us...

there are reports from different countries that some types of glaucoma are associated with blood groups. this cross-sectional study was performed on 400 glaucomatous patients [100 patients in each group of primary open angle glaucoma (poag), chronic angle closure glaucoma (cacg), pseudoexfoliative glaucoma (pexg) and primary congenital glaucoma (pcg)] and 400 blood donors as control group to as...

gamma-Aminobutyric acid (GABA)-gated chloride channel receptors are abundant in the CNS, where their physiological role is to mediate fast inhibitory neurotransmission. In insects, this inhibitory transmission plays a crucial role in olfactory information processing. In an effort to understand the nature and properties of the ionotropic receptors involved in these processes in the honeybee Apis...

temporal resolution must be both sufficiently extensive and Sediment cores collected from the southern basin of Lake Titifine-scaled to describe patterns that appear at the scale of caca (Bolivia/Peru) on a transect from 4.6 m above overflow level the processes of interest. When the affected processes are to 15.1 m below overflow level are used to identify a new centurycertain human activities,...

temporal resolution must be both sufficiently extensive and Sediment cores collected from the southern basin of Lake Titifine-scaled to describe patterns that appear at the scale of caca (Bolivia/Peru) on a transect from 4.6 m above overflow level the processes of interest. When the affected processes are to 15.1 m below overflow level are used to identify a new centurycertain human activities,...

The phas promoter displays stringent spatial regulation, being very highly expressed during embryogenesis and completely silent during all phases of vegetative development in bean, Phaseolus vulgaris. This pattern is maintained in transgenic tobacco and, as shown here, Arabidopsis. Dimethyl sulphate in vivo footprinting analyses revealed that over 20 cis-elements within the proximal 295 bp of t...

1. The isolated, intact heart of the marine arachnid Limulus polyphemus continues to beat in vitro for many hours. Application of ^aminobutyric acid (GABA) decreased the heart beat frequency with a threshold of 3xlO~ 7 moir 1 and an EC50 of 2.0±0.6xlO"moll" (mean±s.D., N = 8). At lO^mol l" 1 and above the heart beat was completely and reversibly inhibited. 2. The agonist potency profile of the ...