C2 domains are regulatory sequence motifs that occur widely in nature. Synaptotagmin I, a synaptic vesicle protein involved in the Ca2+ regulation of exocytosis, contains two C2 domains, the first of which acts as a Ca2+ sensor. We now describe the three-dimensional structure of this C2 domain at 1.9 A resolution in both the Ca(2+)-bound and Ca(2+)-free forms. The C2 polypeptide forms an eight-...

Let M be a point set, C1 and C2 mutually exclusive closed subsets of M, and K a connected subset of M such that (1) K contains no points of the set C1 + C2 and (2) both C1 and C2 contain limit points of K. Then K, together with its limit points in C1 + C2, will be caUed a set K(C1,C2)M. If M has the property that for every two of its mutually exclusive closed subsets Cl, C2 and every connected ...

Let C1 and C2 be strong amalgamation classes of finite structures, with disjoint finite signatures σ and τ . Then C1∧C2 denotes the class of all finite (σ∪τ)-structures whose σ-reduct is from C1 and whose τ -reduct is from C2. We prove that when C1 and C2 are Ramsey, then C1 ∧ C2 is also Ramsey. We also discuss variations of this statement, and give several examples of new Ramsey classes derive...

INTRODUCTION KIR2DS5 is an activating human NK cell receptor of lineage III KIR. These include both inhibitory KIR2DL1, 2 and 3 and activating KIR2DS1 that recognize either the C1 or C2 epitope of HLA-C. In Europeans KIR2DS5 is essentially monomorphic, with KIR2DS5*002 being predominant. Pioneering investigations showed that KIR2DS5*002 has activating potential, but cannot recognize HLA-A, -B, ...

The prevalence of homozygous and heterozygous deficiency of the second component of complement (C2) was determined in patients with rheumatic disease including 137 with systemic lupus erythematosus (SLE), 274 with juvenile rheumatoid arthritis, and 134 with rheumatoid arthritis. 1 C2 homozygous deficient and 19 possible heterozygous deficient individuals were identified by using both immunochem...

This paper presents the Dynamic OODA loop, or DOODA loop for short, a generic model of Command and Control (C2) stemming from Boyd’s OODA loop and cybernetic models of C2. The DOODA loop is formulated in terms of functions that must be accomplished for effective C2, and these functions are then studied in terms of (partially overlapping) processes. The DOODA loop preserves the prescriptive rich...