RNA interference (RNAi) is a useful in vitro research tool, but its application as a safe and effective therapeutic agent may benefit from improved understanding of mechanisms of exogenous siRNA delivery, including cell trafficking and sorting patterns. We report the development of a transfection reagent for siRNA delivery which employs a distinctive non-digestive mode of particle-cell membrane...

The most serious complication of haemophilia A is development of a high-titre factor VIII (FVIII) inhibitor which renders the patient unresponsive to FVIII replacement. Bleeding complications can only be controlled using FVIII-inhibitor bypassing agents but their effect is less certain. The ultimate goal is to eliminate the inhibitor by immune tolerance induction therapy (ITI) using daily high ...

Abstract A common style of argument in the literature on free will and moral responsibility is Manipulation Argument. These tend to begin with a case an agent deterministic universe who manipulated, say, via brain surgery, into performing some action. Intuitively, this not responsible for that Yet, since there no relevant difference, respect whether responsible, between manipulated typical univ...

Contemporarily, convincing evidence is lacking for the existence of micro black holes due to their small masses. In this paper, a specific situation discussed in which Schwarzschild hole, with mass up 1013 kg and hence lifetime longer than universe's age flies towards Earth typical speed an asteroid, (10 km/s). The analysis two-body problem shows that Earth's surface will be tidally affected on...