RNA modifications are ubiquitous in biology, with over 100 distinct modifications. While the vast majority were identified and characterized on abundant noncoding RNA such as tRNA and rRNA, the advent of sensitive sequencing-based approaches has led to the discovery of extensive and regulated modification of eukaryotic messenger RNAs as well. The two most abundant mRNA modifications-pseudouridi...

Abstract Proposals to use technology cool sea surface temperatures have received attention for the potential application of weakening a tropical cyclone ahead landfall. Here, an ocean-mixing aware maximum intensity theory finds that artificial ocean cooling could drastically weaken cyclones over high temperature and deep mixed layer environments, especially fast storm motion speeds. In contrast...

This paper considers inference from multinomial data and addresses the problem of choosing the strength of the Dirichlet prior under a meansquared error criterion. We compare the Maximum Likelihood Estimator (MLE) and the most commonly used Bayesian estimators obtained by assuming a prior Dirichlet distribution with “noninformative” prior parameters, that is, the parameters of the Dirichlet are...

Abstract Objective to analyze the aspects that weaken access viral hepatitis care. Method evaluative research, developed in State of Mato Grosso, with managers Health Department and professionals from reference services. For data collection, interviews were conducted. Content analysis was used a theme-based approach and, for discussion, dimensions model universal health Results The political di...

According  to  a  basic  prediction  made  by  the  Revised  Hierarchical  Model  (RHM),  at  early  stages  of language  acquisition,  strong  L2-L1  lexical  links  are  formed.  RHM  predicts  that  these  links  weaken with  increasing  proficiency,  although  they  do  not  disappear  even  at  higher  levels  of  language development. To test this prediction, two groups of highly proficie...

Professor Victor Neale was a leading paediatrician and respected teacher at a time when the specialty was growing rapidly and employing new professional skills, knowledge and attitudes. The benefits of these developments might be more fully realized by the establishment of a college of Paediatricians. But the consequential loss of affinity with the general medicine of adults and the Royal Colle...

When reform has no direct aggregate effects, but only changes agents’ incentives to act, uncertainty can weaken its effect. Because agents learn about policy change by observing their signals, increasing signal noise makes it harder for agents to know that reform has occurred. When policy changes are difficult to observe, they change agents’ actions less and have less aggregate effect. This is ...