Bullous systemic lupus erythematosus is one of the rare autoantibody mediated skin manifestation of systemic lupus erythematosus (SLE) demonstrating subepidermal blistering with neutrophilic infiltrate histologically. We present a case of a 40-year-old Hispanic female who presented with a several months' history of multiple blistering pruritic skin lesions involving the face and trunk, a photos...

Thirty three patients admitted to the University Department of Dermatology and Venereology, Sestre milosrdnice University Hospital, were included in the study. The purpose of the study was to compare data on age and gender, habits, lesion localization, onset of symptoms and therapy between patients with pemphigus vulgaris and those suffering from bullous pemphigoid. Based on clinical presentati...

The purpose of this paper is to show (1) the use and limitations of the techniques involved in immunofluorescent procedures, (2) to describe the skin diseases in which immunofluorescence is of diagnostic or therapeutic value and (3) to review our experience over the past two years. There are many skin diseases in which diagnosis can be difficult at a histopathological level, let alone for the c...

Autoimmune bullous disorders are a group of severe skin diseases characterized clinically by blisters and erosions of skin and/or mucous membranes. A hallmark of these disorders is the presence of IgG and occasionally IgA autoantibodies that target distinct adhesion structures of the epidermis, dermoepidermal basement membrane, and anchoring fibrils of the dermis. This Review focuses on the pot...

Fig 1. Papules with overlying hemorrhagic crusting located on the proximal arm (underlying bruising is caused by recent trauma to the arm and is not a result of the patient’s hemorrhagic bullous dermatosis). INTRODUCTION Hemorrhagic bullous dermatosis is a rare, generalized skin reaction with unknown pathogenesis, described in association with heparin therapy. Heparin is known to cause injectio...

Basophils are rare cells in the peripheral blood which have capability to infiltrate into skin. Invasion of basophils has been detected pruritic skin diseases, including atopic dermatitis, bullous pemphigoid, chronic spontaneous urticaria and contact dermatitis. In skin, important players inflammatory immune response, as they release Th2 cytokines, interleukin (IL)-4 IL-13, subsequently inducin...

A family of eleven proteins comprises the Janus kinases (JAK) and signal transducers and activators of transcription (STAT) signaling pathway, which enables transduction of signal from cytokine receptor to the nucleus and activation of transcription of target genes. Irregular functioning of the cascade may contribute to pathogenesis of autoimmune diseases; however, there are no reports concerni...

Bullous pemphigoid (BP) and dermatitis herpetiformis (DH) are chronic subepidermal bullous diseases, which progress together with an itch and an inflammatory reaction. These symptoms may be the cause of a phenomenon described in the literature as a neurogenic skin inflammation. Neuropeptides are one of the mediators which take part in this process. The aim of our study was to indicate the expre...