Bullous pemphigoid is an autoimmune skin disease that results in formation of pruritic blisters. Most cases are treated with a combination systemic and topical corticosteroids as well other immunomodulatory drugs. Dupilumab fully human monoclonal antibody acts antagonist against IL4Ra traditionally used the treatment atopic dermatitis. We present 80-year-old man moderate to severe bullous succe...

Bullous pemphigoid is the most common autoimmune subepidermal blistering disease of the skin and mucous membranes. This disease typically affects the elderly and presents with itch and localized or generalized bullous lesions. In up to 20% of affected patients, bullae may be completely absent, and only excoriations, prurigo-like lesions, eczematous lesions, urticated lesions and/or infiltrated ...

Fig 1. Papules with overlying hemorrhagic crusting located on the proximal arm (underlying bruising is caused by recent trauma to the arm and is not a result of the patient’s hemorrhagic bullous dermatosis). INTRODUCTION Hemorrhagic bullous dermatosis is a rare, generalized skin reaction with unknown pathogenesis, described in association with heparin therapy. Heparin is known to cause injectio...

In a comparative study the conventional haematoxylin and eosin staining method was employed concomitantly with the peroxidase-antiperoxidase method in cases of bullous skin diseases. This study includes 40 cases of bullous diseases diagnosed on clinical grounds and confirmed by routine histology using conventional haematoxylin and eosin staining. Skin sections were stained by immunoperoxidase m...

Purpose To report the association of rubeosis iridis with chronic bullous degenerative peripheral retinoschisis. Observations A 63-year-old female presented with acute hyphema and neovascularization of the iris in association with elevated intraocular pressure. Posterior segment examination including imaging revealed no vascular occlusion as a potential cause. However, large, peripheral bullo...

Bullous lupus erythematosus is a rare variant of systemic lupus erythematosus (SLE) and is characterized by autoantibodies to type VII collagen. Co-existence of SLE and human immunodeficiency virus (HIV) infection is extremely rare; the development of bullous lupus in the setting of HIV has been, to our knowledge, reported in the literature only once. We describe a 26-year-old man with an 8-yea...

OBJECTIVES To evaluate the outcomes of amniotic membrane transplantation for symptomatic relief in patients with bullous keratopathy. MATERIAL AND METHOD This retrospective study included 17 eyes (17 patients) with bullous keratopathy presenting with intractable pain or discomfort. The patients were enrolled from January 2000 to December 2004. Amniotic membrane transplantation was performed. ...

are the frequently reported side effects, adverse cutaneous reactions are extremely rare. There are a few reports of acute generalized exanthematous pustulosis caused by faropenem and meropenem. However, bullous skin eruptions have not been reported, yet the various types of bullous drug reactions are bullous fixed drug reactions (FDRs), Stevens–Johnson syndrome and toxic epidermal necrolysis, ...

Background & Objective: Autoimmune bullous diseases are associated with autoimmunity against structural components in the skin and mucous membranes. Autoantibodies are against the intercellular junctions in pemphigus disease and hemidesmosomal unchoring complex in pemphigiod diseases and epidermolysis bullosa aquisita. The tissue-bound and circulating serum autoantibodies can be detected with d...

A 13 years old boy with progressive poikiloderma, bullous lesions in the extremities and photosensitivity is reported. Physical examinations were otherwise normal, his physical development was normal, no other family member had a similar disease. Routin laboratory exams were in the normal limits.Histopathology exams from poikilodermatous skin showed atrophy of the epidermis, liquification degen...