the main objective of the present study was to formulate gastroretentive effervescent sustained release drug delivery systems of risperidone floating tablets with the help of methocel® k15, ethocel® standard 7fp premium, eudragit ® rs100 sustained release polymers to improve its safety profile, bioavailability and patient compliance. risperidone floating tablets were formulated by wet granulati...

the purpose of this work was to study the effect of various permeation enhancers on the permeation of salbutamol sulphate (ss) buccal patches through buccal mucosa in order to improve the bioavailability by avoiding the first pass metabolism in the liver and possibly in the gut wall and also achieve a better therapeutic effect. the influence of various permeation enhancers, such as dimethyl sul...

Purpose: To prepare and characterise ciprofloxacin mucoadhesive buccal films for localised, improved drug delivery in periodontitis. Methods: Ciprofloxacin-loaded buccal films containing 50 mg ciprofloxacin were prepared mucoadhesive polymers sodium cellulose (SCMC) and sodium alginate, using a solvent evaporation method. The films were evaluated in terms of thickness, weight, folding endurance...

Purpose: To prepare and evaluate bioadhesive buccal films of diltiazem hydrochloride (a L-type calcium channel blocker) for overcoming the limitations of frequent dosing, low bioavailability and gastrointestinal discomfort of oral delivery. Methods: Buccal films were prepared by solvent casting technique using sodium carboxymethylcellulose, polyvinyl pyrrolidone K-30 and polyvinyl alcohol. The ...

Purpose: The objective of the study was to evaluate the naturally available Moringa gum as drug carrier and mucoadhesive component in buccal delivery and to compare the bioavailability of Propranolol Hydrochloride buccal tablet with the oral tablet in healthy human volunteers. Material and Methods: The buccal tablets containing various concentration (Formulation1: 10, F2: 20, F3: 30 and F4: 40 ...

delivery of exogenous materials such as nucleic acids, peptides, proteins, and drugs into cells is an important strategy in modern cellular and molecular biology. recently, the development of gene carriers for efficient gene transfer into cells has attracted a great attention. furthermore, lack of effective drug delivery is one of the major problems of cancer chemotherapy. many physical methods...

PURPOSE The purpose of this study was to formulate ketoprofen (KET)-loaded Eudragit L and Eudragit S nanofibers (NFs) by the electrospinning technique for buccal administration to treat oral mucositis as a safe alternative to orally administered KET, which causes gastrointestinal tract (GIT) side effects. MATERIALS AND METHODS NFs were prepared by electrospinning using Eudragit L and Eudragit...