Reactions within the cell should satisfy the law of mass conservation and the second law of thermodynamics. Networks of reactions violating any of these laws are unphysical and cannot occur in nature. In this paper we describe a technique that perturbs an unfeasible network to produce a metabolic network that satisfies the two fundamental laws. This algorithm has been applied to study the metab...

Mục tiêu: nghiên cứu mức độ đồng thuận của các bác sĩ (BS) có kinh nghiệm khác nhau trong chẩn đoán viêm ruột thừa cấp (VRT) dựa trên dấu hiệu cắt lớp vi tính (CLVT). Đối tượng và phương pháp: Nghiên mô tả ngang so sánh 60 trường hợp VRT lâm sàng, đó 30 kết quả sau phẫu thuật là VRT, được chụp CLVT ổ bụng tại Bệnh viện Hữu nghị Việt Đức từ tháng 4 đến 10/2022. Hình ảnh 3 thâm niên (18 năm, 5 nă...

* Correspondence: E.Bullinger@ulg. ac.be Department of Electrical Engineering and Computer Science (Montefiore Institute) and GIGA (Interdisciplinary Cluster for Applied Geno-proteomics), Université de Liège, Belgium • Bioinformatics for Systems Biology by S. Krawetz (Ed.), Springer, February 2009 (2 ed.) ISBN: 978-1-934115-02-2 (BSB) • Systems Biology and Bioinformatics: A Computational Approa...

The application of new information and biotechnologies to infectious disease research provides an opportunity to design, develop and deploy a comprehensive cyberinfrastructure for life sciences. The application of integrative approaches including theory, wet experimentation, modeling and simulation and the leveraging of a strong comparative, evolutionary framework has spawned pathosystems biolo...

7 Matthew R. Hodges and George B. Richerson 8 9 Dept of Physiology, Medical College of Wisconsin, Milwaukee, WI 53226 10 11 Departments of Neurology and Cellular and Molecular Physiology, 12 Yale University, New Haven, CT 06520 13 14 Veteran’s Affairs Medical Center, West Haven, CT 06516 15 16 Address for Correspondence: 17 Matthew R. Hodges 18 BSB-504, Dept of Physiology 19 Medical College of ...

The chemical composition of essential oil extracted from the aerial parts Ballota saxatilis Sieber ex C.Presl Jordan has been elucidated by gas chromatography–mass spectrometry (GC-MS). Additionally, aqueous methanol (BsA), Butanol (BsB) and water (BsW) extracts were screened for their total phenol content (TPC), flavonoid (TFC), antioxidant activities using 2,2 Diphenyl-1-picrylhydrazyl (DPPH)...

This paper details tests on steel-wood-steel connections with thin dowels carried out at the University of British Columbia in Vancouver, Canada. Connections configurations were selected in such a way that the influence of the main parameters such as dowel slenderness ratio, dowel strength, fastener spacing and end distance and the number of dowels could be studied. An important issue of the pa...

UNLABELLED The availability of advanced profile-profile comparison tools, such as PRC or HHsearch demands sophisticated visualization tools not presently available. We introduce an approach built upon the concept of HMM logos. The method illustrates the similarities of pairs of protein family profiles in an intuitive way. Two HMM logos, one for each profile, are drawn one upon the other. The al...

One-class classification techniques are able to, based only on examples of a normal profile, induce a classifier that is capable of identifying novel classes or profile changes. However, the performance of different novelty detection approaches may depend on the domain considered. This paper applies combined one-class classifiers to detect novelty in gene expression data. Results indicate that ...

This work investigates the behavior of two different clustering algorithms, with two proximity measures, in terms of the contents of the partitions obtained with them. An analysis of how the classes are separated by these algorithms, as different numbers of clusters are generated, is also presented. A discussion on the use of these information in the identification of special cases for further ...