نتایج جستجو برای: bruton

تعداد نتایج: 389  

Journal: :Future Oncology 2021

Mantle cell lymphoma is an aggressive B-cell malignancy. Current frontline chemoimmunotherapies produce high response rates but relapse inevitable. Furthermore, the elderly and those with comorbidities are precluded from standard regimens stem transplant, leaving them limited options. Targeted therapies, including Bruton tyrosine kinase inhibitors, effective treatment strategy in mantle lymphom...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 1997
O El-Hillal T Kurosaki H Yamamura J P Kinet A M Scharenberg

Activation of the syk tyrosine kinase occurs almost immediately following engagement of many types of antigen receptors, including Fc receptors, but the mechanism through which syk is activated is currently unclear. Here we demonstrate that Fc receptor-induced syk activation occurs as the result of phosphorylation of the syk activation loop by both src family kinases and other molecules of acti...

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