نتایج جستجو برای: brugada syndrome
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A decade has passed since Pedro and Joseph Brugada (1) discovered an electrocardiographic (ECG) marker for sudden cardiac death in a subset of patients with idiopathic ventricular fibrillation (VF) characterized by ST-segment elevation in the right precordial leads (V1 to V3) with a right bundle branch block pattern. This clinical entity, quickly recognized as the Brugada syndrome, has drawn wi...
‘You have a ticking time-bomb in your body’ is an expression too commonly used by cardiovascular surgeons when counseling patients with asymptomatic aortic aneurysm. Such patients find it difficult to cope with their ‘ticking-bomb’ dilemma—which sooner or later may blow-out their aorta— and often opt for invasive therapy before the ‘risk-vs.benefits’ section of the discussion is over. Based on ...
Brugada syndrome is a potentially lethal ventricular arrhythmia disease with an ECG pattern of ST-segment elevation in leads V1-3 and normal QT interval without structural heart disease. Clinical presentation of Brugada syndrome is characterized by a male predominance with syncope or sudden death, mostly at an average age of 40 years. We report 2 male patients, in whom the diagnosis was made at...
To the Editor: Michowitz et al present an interesting study on the prevalence of familial atrioventricular nodal reentrant tachycardia (AVNRT). They report a prevalence of 127 out of 10 000 of familial AVNRT with a likely autosomal dominant pattern of inheritance (with incomplete penetrance). A potentially important question is whether all the observed cases represent “pure” familial AVNRT or w...
The report of the Second Consensus Conference, published in Circulation in 2005, defined the Brugada syndrome as ST-segment elevation in the right precordial ECG leads (so-called type 1 ECG) and a high incidence of sudden death in patients with structurally normal hearts.1 An autosomal dominant disease with incomplete penetrance, Brugada syndrome has been linked to mutations in SCN5A, the gene ...
mogenic marker for the sudden unexplained death syndrome in Thai men. Circulation 1997; 96: 2595–2600. [7] Priori SG, Napolitano C, Glordano U et al. Brugada syndrome and sudden cardiac death in children. Lancet 2000; 355: 808–9. [8] Corrado D, Buja G, Basso C et al. What is the Brugada syndrome? Cardiol Rev 1999; 7: 191–5. [9] Brugada R, Brugada J, Antzelevitch C et al. Sodium channel blockers...
INTRODUCTION AND OBJECTIVES Little is known about the risks and outcomes of pregnancy in women with Brugada syndrome. We therefore evaluated pregnancy outcomes and the influence of pregnancy in patients with Brugada syndrome. METHODS A retrospective analysis was performed in all pregnant women with Brugada syndrome. We included 104 women with a total of 219 deliveries. RESULTS There were 15...
Brugada syndrome is increasingly recognized as a cause of sudden cardiac death. Many of these patients do not get diagnosed due its dynamic and often hidden nature. We have come a long way in understanding the disease process, and its electrophysiology appears to be intimately linked with sodium channel mutations or disorders. The cardiac rhythm in these patients can deteriorate into fatal vent...
BACKGROUND The Brugada syndrome is an inherited cardiac arrhythmia associated with high risk of sudden death. Although 20% of patients with Brugada syndrome carry mutations in SCN5A, the molecular mechanisms underlying this condition are still largely unknown. METHODS AND RESULTS We combined whole-exome sequencing and linkage analysis to identify the genetic variant likely causing Brugada syn...
Two patients with Brugada syndrome are presented. The ECGs showed right precordial J waves and ST-segment elevation. Patient 1 was resuscitated from nocturnal ventricular fibrillation, patient 2 was asymptomatic. In only patient 1, flecainide was infused causing monomorphic "malignant" ventricular extrasystoles (R on T), demonstrating the deleterious effect of Class IC antiarrhythmic drugs in B...
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