Three simple and sensitive extractive spectrophotometric methods have been described for the assay of terbinafine hydrochloride either in pure form or in pharmaceutical formulations. The developed methods involve formation of coloured chloroform extractable ion-pair complexes of the drug with bromothymol blue (BTB), bromophenol blue (BPB) and bromocresol green (BCG) in acidic medium. The extrac...

Proalbumin Christchurch, a circulating variant of human serum albumin, is secreted from the liver without cleavage of the hexapeptide situated at the N-terminal end of the peptide chain of proalbumin. We compared ligand-binding properties of proalbumin Christchurch and of normal albumin A from the same individual in order to test the effect of the presence of the hexapeptide. The two albumin fo...

A pencil graphite electrode modified with poly (bromocresol green (BCG)) was prepared by electro-polymerization process for the determination of pantoprazole sodium. The surface morphology and structure of poly (BCG) film were characterized by scanning electron microscopy and Fourier transform infrared spectroscopy. The determination of pantoprazole sodium in Britton-Robinson buffer (pH 7.0) wa...

Three new, simple, rapid and sensitive spectrophotometric methods have been developed for the assay of mebendazole (MBD) in bulk drug, tablets and suspension. First method (method A) is based on the formation of a colored ion-pair complex (1:1 drug/dye) of MBD with bromocresol green (BCG) at pH 1.99 ± 0.01 and extraction of complex into chloroform followed by measurement of yellow ion-pair comp...

Coriander (Coriandrum sativum) is one of the medicinal plants which known to contain secondary metabolites such as flavonoids, tannins, terpenoids, saponins, steroids, and alkaloids. Alkaloids have therapeutic effects antimalarials cancer. Research in determining alkaloids coriander was carried out by separating from other substances using soxhlet method extraction with two solvents ethanol n-h...

A direct, extraction-free spectrophotometric method has been developed for the determination of acebutolol hydrochloride (ABH) in pharmaceutical preparations. The method is based on ionpair complex formation between the drug and two acidic dyes (sulphonaphthalein) namely bromocresol green (BCG) and bromothymol blue (BTB). Conformity to Beer’s law enabled the assay of the drug in the range of 0....

Three simple, economical, precise, reliable and reproducible visible spectrophotometric methods (A, B and C) have been developed for the estimation of Levetiracetam in bulk as well as in Tablet formulation. The developed methods A, B and C are based on the formation of chloroform extractable complex of Levetiracetam with Bromocresol green (method A), Bromophenol blue (method B) and Bromothymol ...

The methods for determination of chitosan content recommended in the Chinese Pharmacopoeia and the European Pharmacopoeia are not applicable for evaluation of the extent of deacetylation (deacetylation degree, DD) in chitooligosaccharides (COS). This study explores two different methods for assessment of DD in COS having relatively high and low molecular weights: an acid-base titration with bro...