ONE ofthe grounds on which disturbance of glycolysis has been assumed to be responsible for experimentally induced degeneration of the retina is the observation recorded by Noell (1951) that injection of sodium iodoacetate abolishes the electric response of the retina much more markedly in mammals than in other species. This finding is suggestive in view of the fact that the mammalian retina is...

Currently, there is no three-dimensional structure of D-specific dehalogenase (DehD) in the protein database. We modeled DehD using ab initio technique, performed molecular dynamics (MD) simulation and docking of D-2-chloropropionate (D-2CP), D-2-bromopropionate (D-2BP), monochloroacetate (MCA), monobromoacetate (MBA), 2,2-dichloropropionate (2,2-DCP), d,l-2,3-dichloropropionate (d,l-2,3-DCP), ...

J . R a d h a k r i s h n a n Department of Chemistry, University of Connecticut, Storrs, Connecticut 06268, USA Z. Naturforsch. 84b, 481-487 (1979); received August 15, 1978 Solvolysis, Methylnorbornyl Systems, Norbornan-3,6-dione, 2-exo-Methylnorbornan-6-one 3-Nortricyclyl bromide (11) was transformed in four steps to norbornan-3,6-dione (10). Methyl 4 -hydroxy-2-butynoate (19) was prepared f...

Ethyl-1H-benzotriazol-1-acetate 2 was prepared by reacting 1H-benzotriazole 1 in alcohol with ethyl bromoacetate in presence of anhydrous potassium carbonate, which was treated with hydrazine hydrate under reflux for 1824 hours to obtain the intermediate 1H-benzotriazole-1-acetic acid hydrazide 3. This compound on Schiff’s reaction with aromatic aldehydes in presence of solvent mixture yielded ...

The target pyrrolyl-thiazoldin-4-one inhibitor (PEHT) was synthesized by the cyclization of 2-acetylpyrrole thiosemicarbazone with ethyl bromoacetate, and its chemical structure determined different spectroscopic techniques, such as FT-IR, 1H NMR, 13C NMR. PEHT performance, a mild steel (MS) corrosion inhibitor, in an acidic solution evaluated mass loss (ML), potentiodynamic polarization (PDP),...

In this work, three new quinolone derivatives were prepared by alkylation of 2-oxo-1,2-dihydroquinoline-4-carboxylic acid with ethyl 2-bromoacetate. The synthesized compounds 2-4 characterized using FT-IR, 1H NMR, 13C NMR and mass spectrometry. Crystal structure 4 was determined single crystal X-ray diffraction. optimized structures in gas phase, chemical shifts, molecular electrostatic potenti...

Enzymic properties have been compared in the following five genetic variants of glucose-6-phosphate dehydrogenase from human erythrocytes: the two common variants with normal activity, A and B; the common variant associated with enzyme deficiency, A-; and two new rare variants, "Ijebu-Ode" and "Ita-Bale."The maximal velocity of the enzyme reaction (V(max)) increases steadily with pH over the en...

The antioxidant activity of two synthesized coumarins namely, N-(4,7-dioxo-2- phenyl-1,3-oxazepin-3(2H,4H,7H)-yl)-2-(2-oxo-2H-chromen-4-yloxy)acetamide 5 and N-(4-oxo-2-phenylthiazolidin-3-yl)-2-(2-oxo-2H-chromen-4-yloxy)acetamide 6 were studied with the DPPH, hydrogen peroxide and nitric oxide radical methods and compared with the known antioxidant ascorbic acid. Compounds 5 and 6 were synthes...