background: we studied the patterns of premenopausal and postmenopausal breast cancer incidence and its established risk factors in iran in 2010. in addition, we estimated the 5-year prevalence of breast cancer in the country. methods: we performed an internet and library literature review. we used national cancer registry data, demographic health surveys, national censuses and world bank data ...

Background: Menstrual characteristics may serve as surrogate measures of endogenous estrogen and may be related to breast cancer risk. This case-control study investigated the relationship between menstrual factors and risk of breast cancer incidence in Iranian Center for Breast Cancer (ICBC). Materials and Methods: Forty seven Cases of breast cancer referred to ICBC and 77 controls were studie...

adiponectin is one of the most important members of adipokine family which is widely synthesized and secreted by adipose tissue. the action of adiponectin is via binding to main receptors. it has several actions including regulation of glucose level, lipid homeo­stasis and reproductive system. adiponectin can also influence vascular endothelium via preventing the migration of monocytes. the rol...

Introduction: Diabetes is associated with an increased risk of cancer. Because of the metastatic nature of cancer, the survival of women with breast cancer is decreasing despite receiving various treatments such as chemotherapy, radiotherapy, etc. The aim of this study was to investigate the relationship between diabetes and the risk factors related to the survival of breast cancer patients. M...

background: breast cancer is the first leading cause of cancer-related death in women. pesticides which are excessively used in northern iran are one of the most important risk factors for breast cancer incidence. the cytochrome p450 1a1 (cyp1a1) is a key enzyme in xenobiotics metabolism and snps of its coding gene has been verified to be important in cancer susceptibility. the aim of this stud...

so far several animal and case-control studies have confirmed this hypothesis that dietary fat increases the risk of breast cancer. however, cohort studies have not shown this relationship. the aim of this study was to review the studies on the relationship between dietary fat intake and breast cancer risk among women. electronic database pubmed and google scholar were searched using the

Background: DNA methyltransferase-3B (DNMT3B) is an important enzyme responsible for maintaining the DNA methylation pattern in eukaryotic cells. In this study we have investigated the correlation between the 46359C→T polymorphism in the DNMT3B gene and the risk of breast cancer incidence among sporadic breast cancer patients in Fars Province, Southern Iran.Methods: In this case-control study, ...

background: exposure to endogenous hormones such as estrogen is known as a lifetime breast cancer (bc) risk factor. polymorphisms in genes that are involved in the steroidogenic process, such as cytochrome p450c17alpha ( cyp17) , affect individuals’ susceptibility to bc. in iran, the highest incident of bc is among young women. this study aimed to find prevalence of single nucleotide polymorphi...