OBJECTIVES To assess the level of pain intensity at which patients feel the impetus to ask for a breakthrough cancer pain (BTcP) medication, and level of pain intensity at which patients consider they have achieved acceptable pain control after receiving a BTcP medication. METHODS A consecutive sample of patients who were receiving oral morphine equivalents equal to or more than 60 mg daily, ...

In article number 2007425, Junmin Lee, Ali Khademhosseini, and co-workers present a breakthrough for modeling of non-alcoholic fatty liver disease (NAFLD) based on bioengineered multicellular microtissues liver-on-a-chip system. The consisting four major cell types (primary human hepatocytes, stellate cells, Kupffer endothelial cells) recapitulate the pathogenesis hepatic fibrosis driven by NAF...

the emerging contaminants are commonly derived from municipal, agricultural, and industrialwastewater sources and pathways. these compounds are polar and poorly biodegradable. the dynamicremoval of atenolol from aqueous solutions by activated carbon in fixed bed column systems was investigated. as far as we know, this is the first study reporting the decontamination by adsorption in fixed bed o...

The presentation of science in the media is usually far more optimistic than other areas of reporting; in place of war and famine we have breakthroughs and astonishing discoveries. But the detail — the slow accretion of supporting data and the puzzling incompatibility of some results — is usually ignored. In effect, science stories are ‘edited’ (either by the journalist or by the scientist who ...

Rapid movement of agricultural chemicals through soil to groundwater via preferential flow pathways is one cause of water contamination. Previous studies have shown that time domain reflectometry (TDR) could be used to characterize solute transport in soil. However, previous studies have only scarcely addressed preferential flow. This study presents an extended application of TDR for determinin...

In this research paper, an experimental breakthrough curve for citric acid in an adsorption recovery process was determined by an ion-exchange resin in 20, 35, 55 °C. Also, a mathematical model for breakthrough curve was presented. Among ion exchange resins that have been experienced, many weak and strong basic anionic resins are available such as, IRA-92, IRA-93, IRA-420 and IRA-458 and all of...