Alzheimer’s disease (AD) is a chronic neurodegenerative disorder that accounts for about 60% of all diagnosed cases dementia worldwide. Although there are currently several drugs marketed its treatment, none capable slowing down or stopping the progression AD. The role blood-brain barrier (BBB) plays key in design successful treatment this disease. Nanosized particles have been proposed as suit...

Injuries such as traumatic brain injury and stroke can result in increased blood-brain barrier (BBB) permeability. This increase may lead to water accumulation in the brain tissue resulting in vasogenic oedema. Although the initial injury may be localized, the resulting oedema causes mechanical damage and compression of the vasculature beyond the original injury site. We employ a biphasic mixtu...

traumatic brain injury (tbi) is physical damage to the brain structure which has a high global rate of mortality and morbidity. tbi can cause intense inflammatory response due to accumulation of leukocytes in cerebral matrix and activation of microglia. microglia can differentiate into m1 macrophages or m2 macrophages following the changes in biochemical properties of brain tissue. m1 sub type ...

Thrombosis of the venous system in brain is a cause cerebral infarction, second only to arterial disease, but associated with high levels morbidity and mortality. The clinical picture thrombosis highly variable often presents source confusion physicians. This study aimed establish patients tertiary healthcare center. We collected analysed case records 23 CVT. most predominant presenting complai...

We report the identification and characterization of 2 classes of benzodiazepine binding sites in the embryonic chick CNS. Binding was examined by competition and saturation binding experiments, using as radioligands 3H-flunitrazepam, a classical benzodiazepine anxiolytic, and 3H-Ro5-4864, a convulsant benzodiazepine. The results demonstrate that high-affinity (KD = 2.3 nM) 3H-flunitrazepam bin...

  Abstract   Background: Invasive fungal infection is an opportunistic infection caused commonly   by mucoraccae and aspergillus. It mostly occurs in patients with underlying disease.   Since it has a high mortality and morbidity rate, considering a treatment strategy seems   necessary.   Objective: Since there has not been a clear protocol for treating these patients, we decided   to establish...

Primary central nervous system lymphoma (PCNSL) is a rare cancer that confined to the brain, spinal cord, leptomeninges and eyes. The origin of this type of lymphoma is often type B lymphocytes, and because the central nervous system (CNS) has no lymph nodes or lymphatic vessels, the cause of PCNSL is still uncertain (1). But its source appears to be from lymphocytes located in the CNS (2). Thi...

Introduction: Previous studies on Brain and other Nervous System Cancers (BNSC) and aircrew have shown inconsistent results, possibly due to their relatively small sample sizes; therefore, the current study aimed to increase the precision of risk estimates.Methods: Systematic searches of PubMed and Embase for pertinent studies up to August 2016 were perfo...

Traumatic brain injury (TBI) is physical damage to the brain structure which has a high global rate of mortality and morbidity. TBI can cause intense inflammatory response due to accumulation of leukocytes in cerebral matrix and activation of microglia. Microglia can differentiate into M1 macrophages or M2 macrophages following the changes in biochemical properties of brain tissue. M1 sub type ...