نتایج جستجو برای: brain microvessels
تعداد نتایج: 477159 فیلتر نتایج به سال:
Since the discovery of P-glycoprotein (P-gp) in brain microvessels composing the human blood-brain barrier (BBB), ATP-binding cassette (ABC) transporters have been recognized as bottlenecks in the development and delivery of neuropharmaceuticals. ABC transporters are expressed predominately at the plasma luminal membrane of brain capillary endothelial cells. These ABC transporters are responsib...
related enzymes in isolated brain microvessels. Proc Natl Acad Sci USA 72: 4622, 1975 32. Palmer GC: /3-adrenergic receptors mediate adenylate cyclase responses in rat cerebral capillaries. Neuropharmacology 19: 17, 1980 33. Herbst TJ, Raichle ME, Ferrendelli JA: ,3-adrenergic regulation of adenosine 3'-5'-monophosphate concentration in brain microvessels. Science 204: 330, 1979 34. MacKenzie E...
The chemokines monocyte chemoattractant protein-1 (MCP-1) and macrophage inflammatory protein-1alpha (MIP-1alpha) aid in directing leukocytes to specific locales within the brain and spinal cord during central nervous system inflammation. However, it remains unclear how these chemokines exert their actions across a vascular barrier, raising speculation that interaction with endothelial cells mi...
We have investigated the transcriptomic and/or proteomic patterns of 71 solute carrier (SLC) and organic solute (OST) transporters, 34 ATP-binding cassette (ABC) transporters, and 51 metabolizing enzymes in human brain microvessels. We used quantitative RT-PCR and LC-MS/MS to examine isolated brain microvessels and cortex biopsies from 12 patients with epilepsia or glioma. SLC2A1/GLUT1, SLC1A3/...
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