Hypothermia reduces cell death and promotes recovery in models of cerebral ischemia, intracerebral hemorrhage and trauma. Clinical studies report significant benefit for treating cardiac arrest and studies are investigating hypothermia for stroke and related conditions. Both local (head) and generalized hypothermia have been used. However, selective brain cooling has fewer side effects than sys...

Cineangiographic examination of reindeer exposed to local (hypothalamic) or general heating and cooling revealed that the angular oculi veins are constricted during cold stress but dilated during heat stress. Moreover, during heat stress a segment of the facial vein appeared to be occluded, causing the cold venous return from the nasal mucosa to be routed directly to the cavernous sinus for sel...

OBJECTIVE The purpose of this study was to evaluate the effects of localized brain cooling on blood-brain barrier (BBB) permeability following transient middle cerebral artery occlusion (tMCAO) in rats, by using dynamic contrast-enhanced (DCE)-MRI. MATERIALS AND METHODS Thirty rats were divided into 3 groups of 10 rats each: control group, localized cold-saline (20℃) infusion group, and local...

Many primary sensory neurons are polymodal, responding to multiple stimulus modalities (chemical, thermal, or mechanical), yet each modality is recognized differently. Although polymodality implies that stimulus encoding occurs in higher centers, such as the spinal cord or brain, recent sensory neuron ablation studies find that behavioral responses to different modalities require distinct subpo...

Rats exposed chronically to mild cold (5 degrees C/41 degrees F) develop hypertension and cardiac hypertrophy. This provides a unique model of hypertension that is environmentally induced. The blood renin-angiotensin system (RAS) has been shown to play a role in both initiating and maintaining the high blood pressure (BP) in cold-induced hypertension. The mechanism also appears to involve both ...

Ingmar Kanitscheider, Amanda Brown, Alexandre Pouget, and Anne K. Churchland Department of Brain and Cognitive Sciences, University of Rochester, Rochester, New York; Cold Spring Harbor Laboratory, Cold Spring Harbor, New York; Department of Basic Neuroscience, University of Geneva, Geneva, Switzerland; Gatsby Computational Neuroscience Unit, London, United Kingdom; and Center for Learning and ...

Pascal Grange, Jason W. Bohland, Michael Hawrylycz, Partha P. Mitra 1 Xi’An Jiaotong-Liverpool University, Department of Mathematical Sciences, 111 Ren’Ai Rd, Suzhou, Jiangsu, China, 215123 2 Boston University, College of Health & Rehabilitation Sciences, Boston, MA 02215, United States 3 Allen Institute for Brain Science, Seattle, Washington 98103, United States 4 Cold Spring Harbor Laboratory...

Abstract Background: Vertical head-out water immersion has different physiological effects on the human body system due to hydrostatic pressure and temperatures. This review examines changes in cerebral blood flow metabolism during in-water exercise Method: Systematic research was conducted PubMed, ScienceDirect, Scopus databases, by binary methods. It included 11 articles that met inclusion cr...