Free radicals are highly reactive molecules generated predominantly during cellular respiration and normal metabolism. Imbalance between cellular production of free radicals and the ability of cells to defend against them is referred to as oxidative stress (OS). OS has been implicated as a potential contributor to the pathogenesis of acute central nervous system (CNS) injury. After brain injury...

objective: it is generally agreed that most of the phenomena observed during brain ischemia and reperfusion can be explained by the damage to membrane structure. oxidative stress is resulted in an imbalance between high consumption of oxygen and low levels of endogenous antioxidants. it is known that gallic acid (ga) is a strong antioxidant. the present study was carried out to evaluate the eff...

This study sought to characterize the distribution of phenols and antioxidant activities in Garcinia Indica fruit extract and their inhibition of cyclophosphamide-induced oxidative stress in rat’s brain. The total Phenol content and antioxidant activities of Garcinia Indica fruit extract were determined in vitro and in vivo. The Results of the study revealed that intraperitoneal administration ...

Oxidative stress is a widespread phenomenon in the pathology of neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis. Neuronal cell death due to oxidative stress may causally contribute to the pathogeneses of these diseases. Therefore, neuroprotective antioxidants are considered to be a promising approach to slow down disease progression...

Free radicals are responsible for causing pathogenesis of healthy cells to lose their structures and functions to develop various degenerative diseases that caused due to aging such as cancer, cardiovascular disease, cataracts, immune system decline, brain dysfunction as well as illness caused due to pollution, cigarette smoke, drugs, illness, stress. So, many dieticians believe that the Recomm...

The overall aim of this article is to review current therapeutic strategies for treating AD, with a focus on mitochondrially targeted antioxidant treatments. Recent advances in molecular, cellular, and animal model studies of AD have revealed that amyloid precursor protein derivatives, including amyloid beta (A beta) monomers and oligomers, are likely key factors in tau hyperphosphorylation, mi...

Traumatic brain injury (TBI) continues to be a major contributor morbidity, disability, and mortality in all age groups. Initial damage is accompanied by acute irreversible primary the parenchyma, while subsequent secondary often progresses slowly over months years, thus providing window for therapeutic intervention. The most frequent case which happened excessive oxidative stress calcium relea...

Background: Alpha lipoic acid has both hydrophilic and hydrophobic characteristics is abundantly distributed in cellular membranes the cytoplasm. It among top cell- protective antioxidants. Material methods : The present work investigated possible therapeutic effects of alpha a male rat model brain aging induced by D-galactose. Four equal-sized groups 40 rats were randomly assigned: G1, control...