نتایج جستجو برای: brafv600e
تعداد نتایج: 835 فیلتر نتایج به سال:
BACKGROUND BRAFV600E is the most common mutation in papillary thyroid carcinoma (PTC), and it is associated with high-risk prognostic factors. However, the significance of the BRAF mRNA level in PTC remains unknown. We evaluated the significance of BRAF mRNA expression level by analyzing PTC data from The Cancer Genome Atlas (TCGA) database. METHODS Data from 499 patients were downloaded from...
The comparative analysis of the expression reactive oxygen species-generating NADPH oxidase NOX4 from TCGA data shows that transcript is upregulated in papillary thyroid carcinomas (PTC)-BRAFV600E tumors compared to PTC-BRAFwt tumors. However, a at protein level malignant and non-malignant missing. We explored by immunohistochemistry staining (28 classical forms PTC (C-PTC), 17 follicular varia...
The interaction of programmed cell death-1 and its ligand is widely studied in cancer. Monoclonal antibodies blocking these molecules have had great success but little is known about them in thyroid cancer. We investigated the role of PD-L1 in thyroid cancer with respect to BRAF mutation and MAP kinase pathway activity and the effect of anti PD-L1 antibody therapy on tumor regression and intra-...
Background: The BRAFV600E mutation is a valuable indicator for thyroid cancer diagnosis. This study aimed to develop deep convolutional neural network (DCNN) model based on ultrasound images predict the status of nodules. Methods: were obtained from four hospitals between January 2017 and 2022. We trained validated DCNN primary set center 1 (979 images, 528 patients). consists Conv block, Downs...
To evaluate the clinical relationship between papillary thyroid microcarcinoma (PTMC) and Hashimoto’s thyroiditis (HT). A total number of 168 patients with histologically confirmed PTMC were enrolled into this study and divided into two groups according to the presence (n=49) or absence (n=119) of concurrent HT. The clinicopathological characteristics between two groups were compared, including...
The V600E mutation in the kinase BRAF is frequently detected in melanomas and results in constitutive activation of BRAF, which then promotes cell proliferation by the mitogen-activated protein kinase signaling pathway. Although the BRAFV600E kinase inhibitor vemurafenib has remarkable antitumor activity in patients with BRAFV600E-mutated melanoma, its effects are limited by the onset of drug r...
Purpose The aim of this study is to investigate the predictive value of BRAF V600E mutation for the persistence of papillary thyroid cancer (PTC) after total thyroidectomy and routine central neck dissection. Patients and Methods We collect the clinicopathological data of 288 PTC patients with total thyroidectomy (TT) and routine central neck dissection (CND), and analyzed the relationship betw...
The potential role of AKT/mTOR signalling proteins and its association with the Raf-MEK-ERK pathway was investigated in hairy cell leukaemia (HCL). BRAFV600E expression and activated forms of AKT, mTOR, ERK1/2, p70S6k and 4E-BP1 were immunohistochemically assessed in 77 BM biopsies of HCL patients and correlated with clinicopathological and BM microvascular characteristics, as well as with c-Ca...
We express our thanks to Dr. Cavoli for interest in our case [1] and shared experience of your case. A 60-year-old female with ErdheimChester disease (ECD) suffered from azotemia with bilateral hydronephrosis within 2 years of initial diagnosis. Author regarded a metforminassociated lactic acidosis combined with azotemia as the cause of her presentations. Although nearly 10% of cases with metfo...
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