Determination of seric levels of adenosine deaminase (ADA), an enzyme produced by monocytes/macrophages and lymphocytes, has been used in the diagnosis of human tuberculosis (TB). In the present study, ADA seric activity was evaluated comparatively to the comparative tuberculin test in the diagnosis of bovine tuberculosis. Two hundred fifty-six cattle were classified by origin and by the compar...

Salmonella typhimurium was invariably isolated from our J strain murine leukosis. Immunization of D103 mice with either inactivated Salmonella typhimurium or the cell-free extract of leukosis inhibited the transplantation of leukosis. The adoptive immunization of D103 mice with spleen cells of Strong A mice immunized with either Salmonella or the cell-free extract of leukosis inhibited the tran...

Experimental bovine immunodeficiency-like virus (BIV)-infection and mixed infection of BIV and bovine leukemia virus (BLV) were performed on sheep. BIV proviral DNA and anti-BIV antibodies were persistently detected in all BIV-inoculated sheep. A slight increase in lymphocyte counts was observed in BIV-infected sheep, but the percentages of CD4+ and CD8+ cells in sheep peripheral blood mononucl...

Bovine lymphoma is a common neoplasm in cattle in area where bovine leukosis virus infection is common. Although the typical form of enzootic lymphoma can be easily diagnosed in clinical setting, lymphomatous tissue can cause non specific signs such as abomasal ulcer, ataxia or clinical signs of heart diseases. The aim of this study was to describe echocardiographic findings in 7 cows with a di...

The presence of neoplastic cells in the medullary cavity of bone may have various consequences including erosion of cortical bone, fat and marrow embolism, peripheral blood cytopenias, pathologic fracture, and necrosis of medullary bone and bone marrow elements.'-'O In man, infarction of bone is recognized to have many causes including intramedullary lymphoid tumors. * ,2 ,5,6 In this report, w...

Bovine leukemia virus expression relies on its chromatin organization after integration into the host cell genome. Proviral latency, which results from transcriptional repression in vivo, represents a viral strategy to escape the host immune system and likely allows for tumor progression. Here, we discriminated two types of latency: an easily reactivable latent state of the YR2 provirus and a '...