Periosteum plays a key role in bone repair through activation of residing stem and/or progenitor cells. The molecular signals regulating differentiation and expansion of periosteal stem cells during early repair are poorly understood. Understanding the molecular basis for initiation and completion of bone healing is vital for the success of bone-tissue engineering and regeneration therapy for i...

Biomineralization Article 2200976 by Luiz E. Bertassoni and co-workers presents injectable cell-laden bone-like tissue constructs that show promise as minimally invasive growth factor-free alternatives to bone autografts for repair regeneration of critical sized defects. By approximating the cellular, structural, chemical composition native bone, engineered microconstructs promote native-like m...

Vascularization of tissue-engineered bones is critical to achieving satisfactory repair of bone defects. The authors investigated the use of prevascularized tissue-engineered bone for repairing bone defects. The new bone was greater in the prevascularized group than in the non-vascularized group, indicating that prevascularized tissue-engineered bone improves the repair of bone defects. [Orthop...

OBJECTIVE Cartilage-bone integration is an important functional end point of cartilage repair therapy, but little is known about how to promote integration. We tested the hypothesis that chitosan-stabilized blood clot implant elicits osteoclasts to drilled cartilage defects and promotes repair and cartilage-bone integration. DESIGN Bilateral trochlear defects in 15 skeletally mature rabbit kn...

Bone fractures have a high degree of severity. This is usually result the physical trauma diseases that affect bone tissues, such as osteoporosis. Due to its highly vascular nature, in constant state remodeling. Although those younger ages possess bones with regenerative potential, impact disrupted vasculature can severely recovery process and cause osteonecrosis. commonly seen neck femur, scap...

Macrophages play crucial roles in repair process of various tissues. However, the details in the role of macrophages during bone repair still remains unknown. Herein, we examined the contribution of the tissue fibrinolytic system to the macrophage functions in bone repair after femoral bone defect by using male mice deficient in plasminogen (Plg-/-), urokinase-type plasminogen activator (uPA-/-...

This study redescribes an arthroscopic bridge technique for repair of avulsion of the posterior cruciate ligament. The procedure is performed step-to-step. In this technique we created two bone tunnels in the anterior aspect of the tibia and inferior medial of the tibia tuberosity and then create suture fixation of the fragment using the suture bridge. The arthroscopic bridge technique was used...

Bone tissue has an exceptional quality to regenerate to native tissue in response to injury. However, the fracture repair process requires mechanical stability or a viable biological microenvironment or both to ensure successful healing to native tissue. An improved understanding of the molecular and cellular events that occur during bone repair and remodeling has led to the development of biol...

INTRODUCTION: Previous reports indicated that nonsteroidal anti-inflammatory drugs (NSAIDs) suppress bone repair in vivo. Our previous study further found that ketorolac suppressed bone repair at the early stage of endochondral ossification. Furthermore, we also found that NSAIDs suppressed osteoblast proliferation in vitro, which may be one of the important factors contributing to their inhibi...

The formation of fibrocartilage at the healing site following a rotator cuff tear repair is a major problem in the field of tendon‑bone healing. The present study aimed to enhance the healing of the tendon‑bone interface following rotator‑cuff tear repair by the interposition of hydroxyapatite (HA) encapsulated with transforming growth factor β1 (TGFβ1). Using an acute rotator cuff repair model...