BACKGROUND Conventional dentoalveolar osseous reconstruction often involves the use of graft materials with or without barrier membranes. OBJECTIVE To evaluate the efficacy of bone induction by bone matrix gelatin (BMG), delivered on an absorbable collagen sponge (ACS), compared to a placebo (ACS alone) in human alveolar socket defects. METHODS 20 alveolar sockets from 10 healthy adults wer...

Tissue engineering is a new approach to articular cartilage repair; however, the integration of the engineered cartilage into the host subchondral bone is a major problem in osteochondral injury. The aim of the present work, therefore, was to make a tissue-engineered osteochondral construct from a novel biphasic scaffold in a newly designed double-chamber bioreactor. This bioreactor was designe...

A major goal of biomimetics is the development of chemical compositions and structures that simulate the extracellular matrix. In this study, gelatin-based electrospun composite fibrous membranes were prepared by electrospinning to generate bone scaffold materials. The gelatin-based multicomponent composite fibers were fabricated using co-electrospinning, and the composite fibers of chitosan (C...

Biodegradable hydrogels with three different water contents were prepared through the glutaraldehyde crosslinking of gelatin with an isoelectric point of 5.0 under varied reaction conditions. The objective of this study is to investigate the effect of time period of basic fibroblast growth factor (bFGF) release that is modified by the hydrogel water content, on the bone regeneration. A bone fra...

Surface coating is the simplest surface modification. However, bioactive molecules can not spread well on the commonly used polylactone-type skeletons; thus, the surface coatings of biomolecules are typically unstable due to the weak interaction between the polymer and the bioactive molecules. In this study, a special type of poly(lactide-co-glycolide) (PLGA)-based scaffold with a loosened skel...

INTRUCTION: Synthetic bone graft such as hydroxyapatite[(Ca10(PO4)6(OH)2] (HA) ceramic have been exhibited high tissue compatibility, osteoconductivity and resistance to infection. However, the insufficient bending strength of HA ceramic, probably too tight to bind of BMPs to HA limit its usage[1]. Various hydroxyapatite /collagen composites were developed as potential biomaterials for bone sub...

Introduction: Gelatin is a natural polymer commonly used in biomedical applications combination with other materials due to its high biocompatibility, biodegradability, and similarity collagen, principal protein of the extracellular matrix (ECM). The aim this study was evaluate suitability gelatin as sole material manufacture tissue engineering scaffolds by electrospinning. Methods: electrospun...

Carbonate apatite (CO₃Ap) foam has gained much attention in recent years because of its ability to rapidly replace bone. However, its mechanical strength is extremely low for clinical use. In this study, to understand the potential of gelatin-reinforced CO₃Ap foam for bone replacement, CO₃Ap foam was reinforced with gelatin and the resulting physical characteristics were evaluated. The mechanic...

We report a facile modification of graphene oxide (GO) by gelatin to mimic charged proteins present in the extracellular matrix during bone formation. The bioinspired surface of GO-gelatin (GO-Gel) composite was used for biomimetic mineralization of hydroxyapatite (HA). A detailed structural and morphological characterization of the mineralized composite was performed. Additionally, MC3T3-E1 ce...

BACKGROUND Topography, stiffness, and composition of biomaterials play a crucial role in cell behaviors. In this study, we have investigated biochemical (gene markers), biophysical (roughness), and biomechanical (stiffness) changes during the osteogenic differentiation of preosteoblasts on gelatin matrices. RESULTS Our results demonstrate that gelatin matrices offer a favorable microenvironme...