experimental and clinical studies have shown that intracoronary transplantation of autologous bone marrow mesenchymal stem cells (bmscs) has resulted in regenerated infarcted myocardium and improved left ventricular (lv) function.the aim of this pilot study was to assess the benefical effectsof intracoronary transplantation of bmsc in patients with oldmyocardial infarction (omi). autologous bms...

OBJECTIVE To characterize equine muscle tissue- and periosteal tissue-derived cells as mesenchymal stem cells (MSCs) and assess their proliferation capacity and osteogenic potential in comparison with bone marrow- and adipose tissue-derived MSCs. SAMPLE Tissues from 10 equine cadavers. PROCEDURES Cells were isolated from left semitendinosus muscle tissue, periosteal tissue from the distomed...

BACKGROUND The combination of cells with platelet-rich plasma (PRP) may fulfill tendon deficits and help overcome the limited ability of tendons to heal. PURPOSE To examine the suitability of 3 human cell types in combination with PRP and the potential impact of the tenocyte-conditioned media (CM) to enhance tendon healing. STUDY DESIGN Controlled laboratory study. METHODS Tenocytes, bone...

In this study, we show that matrix dense cortical bone is the more potent compartment of bone than bone marrow as a stromal source for mesenchymal stem cells as isolated from adult rats. Lineage-depleted cortical bone-mesenchymal stem cells demonstrated >150-fold enrichment of colony forming unit-fibroblasts per cell incidence. compared to lineage-depleted bone marrow-mesenchymal stem cells, co...

Bone marrow contains mesenchymal cells that can be isolated and grown in vitro. Using appropriate treatment protocols such cultures can be induced to differentiate to yield osteoblasts, adipocytes, and chondrocytes. However, previous experiments had not addressed the question whether single pluripotent stem cells exist and can give rise to these different cell lineages or whether bone marrow me...

Human mesenchymal stem cells (hMSCs), which also called mesenchymal stromal cells, are multipotent stem cell. Human MSCs typically are positive for the surface markers CD44, CD73, CD90, CD105, CD106, and also negative for hematopoietic markers CD34 and CD45.These cells can be isolated from postnatal bone marrow, adipose tissue, placenta, and scalp tissue, as well as from various fetal tissues. ...

There is currently great interest in the use of mesenchymal stem cells as a therapy for multiple sclerosis with potential to both ameliorate inflammatory processes as well as improve regeneration and repair. Although most clinical studies have used autologous bone marrow-derived mesenchymal stem cells, other sources such as allogeneic umbilical cord-derived cells may provide a more accessible a...

Liver disease is a major health problem that endangers human worldwide. Stem cells have the unique ability to morph or differentiate into different types of within body. In this way, stem can be used seek out damaged liver tissue and regenerate organ itself. Mesenchymal are multipotent self-renew cell types. other words, mesenchymal become variety including adipose tissue, cartilage, muscle, te...

Mesenchymal stem cells (MSCs) show high expression of PD-L1. Exosomes can transmit signals between tumor and stromal cells; however, the effect tumor-derived exosomes on cell signaling pathways is unclear. The PD-L1 in bone marrow mesenchymal (BMMSCs) was detected by western blot RT-PCR. effects gastric cancer line-derived BMMSC migration conditioned medium from educated BMMSCs were analyzed. O...