Total body irradiation (TBI) is a powerful but potentially hazardous tool used in the eradication of malignant cells and the suppression of the immune system to enable bone marrow engraftment. The occasion of its use is confined to bone marrow transplantation (BMT) in malignant disorders and some non-malignant haematological and metabolic conditions and is accompanied by high dose chemotherapy....

Total body irradiation (TBI) is a powerful but potentially hazardous tool used in the eradication of malignant cells and the suppression of the immune system to enable bone marrow engraftment. The occasion of its use is confined to bone marrow transplantation (BMT) in malignant disorders and some non-malignant haematological and metabolic conditions and is accompanied by high dose chemotherapy....

The determination of the dose delivered to the body during Total Body Irradiation (TBI) is not easy, as direct measurements are impossible. This article presents the intention to develop a systematic and simple method for absorbed dose determination in(60)Co TBI using mid plane dose factors (MDF) and external measurements, i.e. entrance and exit dose readings by semiconductor detectors. In orde...

Malignant disorders are still far from being successfully managed in spite of the apparent progress achieved by surgical treatment, high energy radiotherapy (RT) and chemotherapy (CHT). They keep being the second most frequent cause of lethal outcomes both in Bulgaria and in most countries of the world. One of the promising approaches to increasing the efficaciousness of treatment is developmen...

PURPOSE To evaluate how irradiation affects thyroid autoimmunity in mouse models of Hashimoto's thyroiditis and Graves' hyperthyroidism. MATERIALS AND METHODS Non-obese diabetic (NOD)-H2(h4) mice spontaneously develop anti-thyroglobulin (Tg) antibodies and thyroiditis when supplied with sodium iodine (NaI) in the drinking water. BALB/c mice develop anti-thyrotropin receptor (TSHR) antibodies ...

Ionizing irradiation induces acute and chronic injury to tissues and organs. Applications of antioxidant therapies for the management of ionizing irradiation injury fall into three categories: (1) radiation counter measures against total or partial body irradiation; (2) normal tissue protection against acute organ specific ionizing irradiation injury; and (3) prevention of chronic/late radiatio...

Kay and coworkers (1) have shown an increased excretion of taurine by rats after total body x-irradiation. It has been demonstrated previously (24) that methionine, cysteine, and glutathione are precursors of taurine. In view of the well established effect of irradiation on sulfhydryl groups described by Barron and his associates (5-7), it seems probable that the increase in the excretion of ta...

Tumors of the pancreatic body and tail are uncommon. They have a propensity to present late and often attain a large size with local invasion before they produce any clinical symptoms. The current review aims at comprehensively analysing these tumors with respect to their pathology, presentation, the investigation of these tumors, and finally the latest trends in their surgical and medical mana...

Kay and coworkers (1) have shown an increased excretion of taurine by rats after total body x-irradiation. It has been demonstrated previously (24) that methionine, cysteine, and glutathione are precursors of taurine. In view of the well established effect of irradiation on sulfhydryl groups described by Barron and his associates (5-7), it seems probable that the increase in the excretion of ta...