After repair of a Bochdalek diaphragmatic hernia, shunting of blood away from the lungs produced progressive hypoxaemia in a neonate. Changes in plasma concentrations of the vasoconstrictor prostanoid thromboxane were associated with changes in pulmonary vascular resistance in this infant. Plasma concentrations of the vasodilator prostanoid prostacyclin were also monitored during acute changes ...

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An 81-year-old chronic smoker with known chronic obstructive pulmonary disease (COPD) presented with a 2-day history of dyspnoea and dry cough in January 2012. His oxygen saturation was normal, but physical examination revealed occasional expiratory wheezing and decreased air entry over the right lower zone. The complete blood picture showed no leukocytoses. The patient was initially managed as...

Incidence Congenital diaphragmatic hernia (CDH) refers to a congenital defect in the posterolateral diaphragm at the “foramen of Bochdalek.” It is a relatively common cause of neonatal respiratory distress with an overall incidence between 1:2000 and 1:5000 live births. CDH accounts for about 90% of congenital diaphragmatic defects. Eighty to ninety percent of congenital diaphragmatic hernias o...

Diaphragmatic rupture during labor is uncommon and generally occurs in patients with a history of congenital diaphragmatic hernia or traumatic abdominal or chest injury. We present a case of a 41-year-old woman who presented with abdominal pain, vomiting and hypoventilation four days after a full-term home delivery. Chest radiography suggested the presence of a ruptured diaphragm, and laparotom...

Tetrasomy of the short arm of chromosome 9 constitutes a rare condition resulting in a well clinically recognized syndrome. In our case, in addition to the characteristic phenotype at birth, the existence of a hernia-type Bochdalek diaphragmatic defect was found. Cytogenetic analysis revealed a nonmosaic case of an isochromosome of the entire short arm of chromosome 9 with no involvement of the...