Bone morphogenetic proteins (BMPs) regulate various biological processes, mostly mediated by cells of mesenchymal origin. However, the roles of BMPs in epithelial cells are poorly understood. Here, we demonstrate that, in polarized epithelial cells, BMP signals are transmitted from BMP receptor complexes exclusively localized at the basolateral surface of the cell membrane. In addition, basolat...

This study evaluated the best management practices on how to manage soil losses from catchment and reduce sediment load into a dam reservoir. aimed evaluate relationship of runoff, loss, yield with practice (BMP) scenarios in GeoWEPP environment for selected three micro-watersheds (hot spot areas) Megech watershed, upper Blue Nile Basin. The impacts four agricultural BMP scenarios, including fo...

Abstract Small-scale aquaculture systems can contribute significantly to food and nutritional security, poverty alleviation, rural development, especially in developing countries. However, the intensification of often has negative environmental outcomes. The adoption diversification practices (e.g. polyculture, pond-dike cropping (PDC)) better management (BMPs) been identified as a possible app...

The pattern of feather buds in a tract is thought to result from the relative ratios between activator and inhibitor signals through a lateral inhibition process. We analyse the role of Drm/Gremlin, a BMPs antagonist expressed during feather pattern formation, in the dermal precursor, the dense dermis, the interbud dermis and in the posterior dermal condensation. We have altered the activity of...

The present study examined the correlation between the level of activity neuron B52 and the transition from protraction to retraction phases of buccal motor patterns (BMPs) and the termination of the BMPs. The level of activity in B52 during the protraction phase was positively correlated with the duration of that phase. A second burst of activity in B52 was associated with the termination of t...

In 1978, the Wisconsin Legislature committed to protecting water quality by enacting the Nonpoint Source Water Pollution Abatement Program. Through this program, cost-share money is provided—within priority watersheds—to control sources of nonpoint pollution. Most of the cost-share dollars for rural watersheds have been used to implement barnyard Best Management Practices (BMPs) because barnyar...

Uncertainty of best management practice (BMP) effectiveness is an important factor in the development watershed plans. This study explored uncertainty BMP reducing total nitrogen (TN) load owing to hydrological parameters, thereby improving their reliability. A model, annualized agricultural non-point source pollution (AnnAGNPS), was employed evaluate four potentially feasible BMPs (i.e., ripar...

Limb development, a complicated biological event that includes diverse processes such as three-dimensional patterning, cartilage and bone differentiation and programmed cell death, or apoptosis, is regulated by a network of signal molecules that work in concert to ensure proper morphogenesis. Bone Morphogenetic Proteins (BMPs), members of the TGF superfamily, play a pivotal role in the signalin...

The regeneration of bone is a remarkable, complex physiological process, and BMPs are a formidable clinical tool to promote its regeneration. By defining roles played by BMPs in developmental biology and bone regeneration, significant progress has been made to identify cell-signaling molecules and their regulators. For example, the regulators of BMPs that include noggin, chordin, cerberus, dan,...

In the developing axial skeleton, sequential sonic hedgehog (SHH) and bone morphogenetic protein (BMP) signals are required for specification of a chondrogenic fate in presomitic tissue. A similar paradigm is thought to operate in the limb, but the signals involved are unclear. To investigate the nature of these signals, we examined BMP action in mesenchymal populations derived from the early m...