نتایج جستجو برای: bmp 2 peptide

تعداد نتایج: 2649874  

Journal: :Acta Biomaterialia 2016

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2010
Elvira Valera Michael J. Isaacs Yasuhiko Kawakami Juan Carlos Izpisúa Belmonte Senyon Choe

BACKGROUND Bone Morphogenetic Protein (BMP) signaling pathways are involved in differentiation of stem cells into diverse cell types, and thus BMPs can be used as main guidance molecules for in vitro differentiation of human stem cells. METHODOLOGY/PRINCIPAL FINDINGS We have analyzed the ability for inducing differentiation of the heterodimer BMP-2/BMP-6 (BMP-2/6) compared to the homodimers B...

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Journal: :Dental materials journal 2017
Xiaojing Zhu Hui Zhang Xinchun Zhang Chengyun Ning Yan Wang

To fabricate a sustained-release delivery system of bone morphogenetic protein (BMP-2) on titanium surface, explore the effect of BMP-2 concentration on the loading/release behavior of BMP-2 and evaluate the cell compatibility of the system in vitro, pure titanium specimens were immersed into supersaturated calcium phosphate solutions (SCP) containing 4 different concentrations of BMP-2: 0, 50,...

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Journal: :The Journal of biological chemistry 2008
Karen Lavery Pamela Swain Dean Falb Moulay Hicham Alaoui-Ismaili

Bone morphogenetic proteins (BMPs) are members of the transforming growth factor-beta superfamily of growth factors and are used clinically to induce new bone formation. The purpose of this study was to evaluate receptor utilization by BMP-2, BMP-4, BMP-6, and BMP-7 in primary human mesenchymal stem cells (hMSC), a physiologically relevant cell type that probably mediates the in vivo effects of...

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2015
Yozo Mitsui Hiroshi Hirata Naoko Arichi Miho Hiraki Hiroaki Yasumoto Inik Chang Shinichiro Fukuhara Soichiro Yamamura Varahram Shahryari Guoren Deng Sharanjot Saini Shahana Majid Rajvir Dahiya Yuichiro Tanaka Hiroaki Shiina

We investigated whether impaired regulation of bone morphogenetic protein-2 (BMP-2) via epigenetic pathways is associated with renal cell carcinoma (RCC) pathogenesis. Expression and CpG methylation of the BMP-2 gene were analyzed using RCC cell lines, and 96 matched RCC and normal renal tissues. We also performed functional analysis using BMP-2 restored RCC cells. A significant association of ...

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Journal: :Molecular cancer research : MCR 2004
Elaine M Langenfeld John Langenfeld

Bone Morphogenetic Protein-2 (BMP-2) is highly overexpressed in the majority of patient-derived lung carcinomas. However, a mechanism revealing its role in cancer has not been established. Here we report that BMP-2 enhances the neovascularization of developing tumors. Recombinant BMP-2 stimulated blood vessel formation in tumors formed from A549 cells injected s.c. into thymic nude mice. Recomb...

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Journal: :Material Sciences 2016

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Journal: :Molecular cancer research : MCR 2005
Elaine M Langenfeld Yingxin Kong John Langenfeld

Bone morphogenetic protein-2 (BMP-2) is an evolutionary conserved protein that is essential for embryonic development. BMP-2 is highly expressed in approximately 98% of human lung carcinomas with little expression in normal lung tissues. BMP-2 has been shown to enhance mobility, invasiveness, and metastasis of cancer cell lines. During development, BMP-2 induces the proto-oncogene phosphoinosit...

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2013
Nikolina Basic-Jukic Tvrtko Hudolin Petar Kes Marijana Coric Eva Pasini

Introduction. Bone morphogenetic protein-2 (BMP-2) is a member of BMP family of proteins. In human, it has role in skeletal repair and regeneration, as well as in heart formation. Kidneys of BMP-2 heterozygous null mutant mice have normal gross anatomy, but exhibit increased ureteric bud branching. Dysregulation of BMP-2 signaling has been suggested in carcinogenesis. Methods. We determined BMP...

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Journal: :The Journal of biological chemistry 2001
E Haÿ J Lemonnier O Fromigué P J Marie

Bone morphogenetic protein-2 (BMP-2), a member of the transforming growth factor-beta (TGF-beta) family, regulates osteoblast differentiation and bone formation. Here we show a novel function of BMP-2 in human osteoblasts and identify a signaling pathway involved in this function. BMP-2 promotes apoptosis in primary human calvaria osteoblasts and in immortalized human neonatal calvaria osteobla...

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