نتایج جستجو برای: blood parasite
تعداد نتایج: 719953 فیلتر نتایج به سال:
In Plasmodium falciparum, the causative agent of human malaria, the catalytic subunit gene of cAMP-dependent protein kinase (Pfpka-c) exists as a single copy. Interestingly, its expression appears developmentally regulated, being at higher levels in the pathogenic asexual stages than in the sexual forms of parasite that are responsible for transmission to the mosquito vector. Within asexual par...
It seems obvious that the number of pathogens should be important in the pathogenesis of an infectious disease [1,2]. The relationship between the pathogen load and severity is one of the most fundamental questions, and yet, strangely, one of the most difficult to answer [3]. One reason for this is that it is often rather difficult to determine the total pathogen load in an infected host, parti...
Nearly one million people are killed every year by the malaria parasite Plasmodium . Although the disease-causing forms of the parasite exist only in the human blood, mosquitoes of the genus Anopheles are the obligate vector for transmission. Here, we review the parasite life cycle in the vector and highlight the human and mosquito contributions that limit malaria parasite development in the mo...
Haemoparasites are one of the most important groups bird parasites, with emphasis on genera Haemoproteus, Plasmodium, Leucocytozoon and Trypanosoma. Zoos sustain different wild animals valuable tools for education conservation species. The conditions captive differ from animals, as zoos have sufficient availability food throughout year, protection against predators veterinary care animals. This...
OBJECTIVE To determine the impact of percentage parasitemia and clinical features on morbidity and mortality in patients with P. falciparum malaria. STUDY DESIGN Case series. PLACE AND DURATION OF STUDY Department of Medicine, Medical Unit II, Jinnah Postgraduate Medical Centre, Karachi, Pakistan from May to November 2005. PATIENTS AND METHODS Seventy-six adult patients of smear positive ...
Theoretical arguments and some mathematical models of host-parasite coevolution (e.g. [16]) suggest host immunity as the driving source for the evolution of parasite virulence. Imperfect vaccines in particular, can play the role and recent work [7] sets to test these ideas experimentally, using the mouse malaria model, Plasmodium chabaudi. To this end the authors evolve parasite lines in immuni...
The efficacy of repeated doses of Dinazene® in Albino rats experimentally infected with Trypanosoma brucei (Gboko strain) was investigated. A total of 30 adult female Albino rats weighing 130-190 g were used for the study. They were assigned to six groups (groups A-F) of five rats each. Groups A-D were infected intraperitoneally with 1.0 × 106 trypanosomes in 400 μL of PBS diluted blood while g...
The human malaria parasite Plasmodium falciparum requires efficient egress out of an infected red blood cell for pathogenesis. This egress event is highly coordinated and is mediated by several signaling proteins, including the plant-like Pfalciparum calcium-dependent protein kinase 5 (PfCDPK5). Knockdown of PfCDPK5 results in an egress block where parasites are trapped inside their host cells....
We describe two improved assays for in vitro and in vivo screening of inhibitors and chemicals for antimalarial activity against blood stages of the rodent malaria parasite, Plasmodium berghei. These assays are based on the determination of bioluminescence in small blood samples that is produced by reporter parasites expressing luciferase. Luciferase production increases as the parasite develop...
About 60% of emerging infectious diseases in humans are of zoonotic origin. Their increasing number requires the development of new methods for early detection and monitoring of infectious agents in wildlife. Here, we investigated whether blood meals from hematophagous flies could be used to identify the infectious agents circulating in wild vertebrates. To this aim, 1230 blood-engorged flies w...
نمودار تعداد نتایج جستجو در هر سال
با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید