Coagulation factors belong to a family of plasma glycosylated proteins that should be activated for appropriate blood coagulation. Congenital deficiencies of these factors cause inheritable hemorrhagic diseases. Factor VII (FVII) deficiency is a rare bleeding disorder with variable clinical symptoms. Various mutations have been identified throughout the F7 gene and can affect all the protein do...

T HE EXACT role of the platelet in blood coagulation is the subject of considerable controversy. Although thrombocytopenic plasma exhibits retarded coagulation, a prolonged clotting time is rare in thrombocytopenic purpura. ‘ This has been explained by the theory that even in severe thrombocytopenia sufficient thromboplastin is elaborated to produce normal coagulation.4 In any event, the hemorr...

the mean percentage of cryptogenic strokes among ischemic strokes is 31%, of which one-third may be associated with patent foramen ovale. the foramen ovale is required for blood flow through the fetal atrial septum.  it is formed as of the fourth week of gestation, and this leads to right-left interatrial shunt that allows the passage of oxygenated blood to systemic circulation. in 75% of cases...

Angiogenesis is a multi-factorial process involving endothelial cells, pericytes, macrophages, angiogenic factors and inhibitors. It plays a fundamental role in many physiological and pathological processes such as wound healing and atherosclerosis. Haemostasis is the arrest of blood loss from damaged blood vessels involving platelet adhesion, activation and blood coagulation. Recent studies su...

Bleeding is a common problem in major trauma. Coagulopathy could be detected in approximately 25% of all trauma patients on arrival in the emergency room. The reasons for that are blood loss, dilution of the remaining coagulation factors by fluids not containing coagulation factors, consumption of coagulation factors and hyperfibrinolysis. Hypothermia and acidosis are also well described contri...

Abstract Purpose of Review Coagulopathy is a complex pathological condition manifested through the insufficient or excessive tendency to form blood thrombi, which can be caused by trauma and surgery. A promising strategy mitigate coagulopathy balanced restoration generation thrombin — main enzyme in blood-coagulation system. We review studies focusing on thrombin, traumatic coagulopathy, hemost...

The role of coagulation factors in diabetic retinopathy was studied in non-insulin-dependent diabetic patients. Patients with retionopathy had higher levels of beta thromboglobulin, von Willebrand factor and fibrinogen levels compared to diabetics without retinopathy and controls. Serum magnesium levels were not significantly different between the groups studied. The role of coagulation factors...

background: direct thrombin inhibitors and factor xa inhibitors are gaining popularity as alternatives to warfarin for patients requiring anticoagulation. toxicity due to these medications is difficult to manage because overdose experience is very limited and there is no clear guidance on when or whether to use antidote in this setting. case presentation: a 50-year-old man with normal renal fun...

In recent years, the dysfunction of the haemostatic system in relation to the clinical complications from arterioscleroses and cardiovascular diseases has become more recognised. Blood coagulation and fibrinolysis comprise two important physiological systems, which are regulated by a balance between activators and inhibitors. Activation of blood coagulation is associated with accelerated clot f...