this study has examined the relationship between the xpd lys 751 gln polymorphism and colorectal cancer in 88 patients and their 88 age and sex-matched controls. genomic dna from peripheral whole blood was extracted using standard method to determine the genotype of subjects with rflp-pcr analysis. although this study shows cancer patients harbor more heterozygous genotype (xpd lys 751 gln) (or...

Background: Alteration in peripheral blood lymphocytes (PBLs) is usually investigated to provide an evidence of the host immune responses to tumor antigens. The tumor infiltrating NK cells interact most closely with the tumor cells and more accurately reflect tumor host interactions. Objective: To analyze peripheral blood and tumor associated Natural Killer (NK) cells in patients with breast ca...

In the blood of cancer patients, some nucleic acid fragments and tumor cells can be found that make it possible to trace tumor changes through a simple blood test called “liquid biopsy”. The main components of liquid biopsy are fragments of DNA and RNA shed by tumors into the bloodstream and circulate freely( ctDNAs and ctRNAs). tumor cells which are shed into the blood (circulating tumor cells...

Background: Given that various types of cancer are major causes of death among children and there is no comprehensive study investigating the simultaneous effect of ifosfamide and mesna in the treatment of patients with various types of cancer in our country, this study aimed to assess the effect of ifosfamide and mesna in the treatment of children with various types of cancer. Materials and M...

Leukemia is a blood disease which is caused by the inhibition of differentiation and an increased proliferation rate. Nature has been known as a rich source of medically useful substances. High diversity of bioactive molecules extracted from marine invertebrates, makes them ideal candidates for cancer researches. The study has been done to investigate cytotoxic effects of dichloromethane brittl...

background: quantification of radiation-induced apoptosis in peripheral blood lymphocytes (pbls) has been proposed as a possible screening test for cancer-prone individuals and also for the prediction of normal tissue responses after radiotherapy. materials and methods: the neutral version of the comet assay (single-cell gel electrophoresis) was used 24, 48, 72 hours after irradiation with 8 gy...

Background: Regulatory T Cells (Tregs) and Myeloid-Derived Suppressor Cells (MDSCs) are two main regulatory cells modulating the immune responses in inflammation and cancer. Objective: To investigate and compare Tregs and MDSCs in peptic ulcer and gastric cancer. Methods: Patients with dyspepsia were selected and divided into three groups of non-ulcer dyspepsia (NUD, n=22), peptic ulcer disease...

Breast cancer is the second major cause of death in world. accounts for 16% all deaths worldwide. Most methods detecting breast very expensive and difficult such as mammography. The objective this research paper through blood analysis using J48 algorithm which will serve alternative to these methods.
 was used classify 116 instances also,10-fold cross validation holdout procedure were coup...

Leukemia is a blood disease which is caused by the inhibition of differentiation and an increased proliferation rate. Nature has been known as a rich source of medically useful substances. High diversity of bioactive molecules extracted from marine invertebrates, makes them ideal candidates for cancer researches. The study has been done to investigate cytotoxic effects of dichloromethane brittl...