N-Methyl-D-aspartate (NMDA) receptors are modulated by extracellular spermine and protons and are blocked in a voltage-dependent manner by spermine and polyamine derivatives such as N1-dansyl-spermine (N1-DnsSpm). The effects of mutations in the first and third transmembrane domains (M1 and M3) and the pore-forming loop (M2) of NMDA receptor subunits were studied. Surprisingly, some mutations i...

Most professional women step off the career fast track at some point. With children to raise, elderly parents to care for, and other pulls on their time, these women are confronted with one off-ramp after another. When they feel pushed at the same time by long hours and unsatisfying work, the decision to leave becomes even easier. But woe to the woman who intends for that exit to be temporary. ...

Receptor activity-modifying proteins (RAMPs) interact with and modify the behavior of the calcitonin receptor (CTR) and calcitonin receptor-like receptor (CLR). We have examined the contribution of the short intracellular C terminus, using constructs that delete the last eight amino acids of each RAMP. C-Terminal deletion of individual RAMPs had little effect on the signaling profile induced wh...

The balanced vehicular traffic model is a macroscopic model for vehicular traffic flow. We use this model to study the traffic dynamics at highway bottlenecks either caused by the restriction of the number of lanes or by on-ramps or off-ramps. The coupling conditions for the Riemann problem of the system are applied in order to treat the interface between different road sections consistently. O...

The balanced vehicular traffic model is a macroscopic model for vehicular traffic flow. We use this model to study the traffic dynamics at highway bottlenecks either caused by the restriction of the number of lanes or by on-ramps or off-ramps. The coupling conditions for the Riemann problem of the system are applied in order to treat the interface between different road sections consistently. O...

Large-scale weather patterns and their variability can influence both the amount of wind power production its temporal variation, i.e., ramps. In this study, we use a self-organizing map to cluster hourly sea level pressure into discrete number patterns. The dependency ramps on these is studied for Belgian offshore farm fleet. A newly developed wavelet-surrogate ramp-detection algorithm used id...