To overcome the problem of multidrug resistance, we investigated the effectiveness of phosphrothioate antisense oligonucleotides (MDR1-AS) in suppressing multidrug resistance gene (mdr1) expression in drug-resistant acute myelogenous leukemia (AML) blast cells and the K562 adriamycin-resistant cell line K562/ADM. The percentage of cells with the mdr1 gene product P-glycoprotein (P-gp) was decre...

in this work the effect of the accuracy of a fae detonation modeling on the generated blast wave is investigated. first, a one-dimensional numerical simulation with a reduced chemical kinetics of c2h2-o2-ar, involving 25 elementary reactions, is used as the base model. the properties of the blast calculated with this model is compared with those of simpler models, the similarity solution of tay...

Neuropsychiatric symptom development has become more prevalent with 270,000 blast exposures occurring in the past 10 years in the United States. How blast injury leads to neuropsychiatric symptomology is currently unknown. Preclinical models of blast-induced traumatic brain injury have been used to demonstrate blood-brain barrier disruption, degenerative pathophysiology, and behavioral deficits...

BACKGROUND The widespread use of explosives by modern insurgents and terrorists has increased the potential frequency of blast exposure in soldiers and civilians. This growing threat highlights the importance of understanding and evaluating blast injury risk and the increase of injury risk from exposure to repeated blast effects. METHODS Data from more than 3,250 large animal experiments were...

The intensity and type of trauma inflicted on a bod y by blast overpr essure are related to man y facto rs. Among them, body orientation. In order to study the effect of body orientation, detailed models of 2D horizontal slices of human and sh eep thoraces have been developed and va lidated with the limited data available in the open literature. The main goal o f this stud y is to verify if the...

Blast induced traumatic brain injury (bTBI) is a serious concern for military personnel exposed to primary blast. Computational models and imaging diagnostics are useful tools that are commonly used to study mechanical response of the brain during trauma, but rely on information about the mechanical property changes due to injury. In this study, thirty adult, male Sprague-Dawley rats were expos...

Interleukin-1 (IL-1) has recently been reported to play an important role in acute myelogenous leukemia (AML) blast proliferation. We therefore investigated the effect of soluble IL-1 receptors (sIL-1R) and IL-1 receptor antagonist (IL-1RA) on the growth of AML bone marrow blast progenitors from 25 patients. In the AML blast colony culture assay, sIL-1R and IL-1RA inhibited blast colony-forming...

To compensate for the extremely low penetration efficiency of the original PDS/1000-He Bio Rad biolistic device and the deleterious blast effect, design modifications have been made to the launching module. These modifications were evaluated on Bombyx mori embryos and fragile tissues, such as oocytes and imaginal wing disks. The original floppy macrocarrier was replaced by a rigid macrocarrier ...

blast (magnaporthe grisea) is the most important disease of rice in mazandaran province, north of iran, which causes severe damages annually on susceptible cultivars. tarom mahalli is a local aromatic cultivar with high cooking quality and marketability, but very susceptible to blast. to protect this cultivar and similar susceptible cultivars against rice blast, farmers have to use high amounts...

grain yield loss in rice (oryza sativa l.) caused by blast disease, magnaporthe grisea (hebert) barr, is a major concern of rice growers worldwide. blast is considered as the most injurious disease of rice in iran, resulting in severe loss especially to susceptible rice cultivars. in order to assess yield loss caused by blast pathogen and develop an appropriate model, different disease onsets a...