In embryonic stem (ES) cells, developmental regulators have a characteristic bivalent chromatin signature marked by simultaneous presence of both activation (H3K4me3) and repression (H3K27me3) signals and are thought to be in a 'poised' state for subsequent activation or silencing during differentiation. We collected eleven pairs (H3K4me3 and H3K27me3) of ChIP sequencing datasets in human ES ce...

Bivalent gene is a gene marked with both H3K4me3 and H3K27me3 epigenetic modification in the same area, and is proposed to play a pivotal role related to pluripotency in embryonic stem (ES) cells. Identification of these bivalent genes and understanding their functions are important for further research of lineage specification and embryo development. So far, lots of genome-wide histone modific...

When switching tasks, occasionally responding to bivalent stimuli (i.e., stimuli with relevant features for two different tasks) slows performance on subsequent univalent stimuli, even when they do not share relevant features with bivalent stimuli. This performance slowing is labelled the bivalency effect. Here, we investigated whether the bivalency effect results from an orienting response to ...

In embryonic stem (ES) cells, developmental regulators have a characteristic bivalent chromatin signature marked by simultaneous presence of both activation (H3K4me3) and repression (H3K27me3) signals and are thought to be in a ‘poised’ state for subsequent activation or silencing during differentiation. We collected eleven pairs (H3K4me3 and H3K27me3) of ChIP sequencing datasets in human ES ce...

CpG islands (CGI) marked by bivalent chromatin in stem cells are believed to be more prone to aberrant DNA methylation in tumor cells. The robustness and genome-wide extent of this instructive program in different cancer types remain to be determined. To address this issue we developed a user-friendly approach to integrate the stem cell chromatin signature in customized DNA methylation analyses...

Unlike BCR and secreted Ig, TCR expression is not thought to occur in a bivalent form. The conventional monovalent model of TCR/CD3 is supported by published studies of complexes solubilized in the detergent digitonin, in which bivalency was not observed. We revisited the issue of TCR valency by examining complexes isolated from primary αβ T cells after solubilization in digitonin. Using immuno...

A recent technique involving the use of paper electrophoresis is described for the study of equilibria in binary complex systems in solution. The stability constants of the ML and ML2 complex species of some metal ions, namely beryllium(II) and cobalt(II), with hydroxyproline were determined in 0.1 mol L perchloric acid and a temperature of 35 °C. The logarithm stability constants of the ML and...

S Benzimidazoles act as good ligand to transition metal ions and they exhibit several coordination modes. The synthesis of hetero-chelates of the type ML2.2H2O has been reported here.The metal complex of Co(II) and Ni(II) Complexes have been synthesized with 6-(difluoromethoxy)-2-[(3,4dimethoxypyridin-2-yl)methylsulfinyl]-1H-benzo[d]imidazole (Pantoprazole). Pantoprazole is a proton pump inhibi...

AbstractBioactive glass with frame of SiO2-CaO-P2O5-ZnO-MgO-SrO was prepared using quick alkali mediated sol-gel process. The functional group analysis, morphology, composition and phase analysis of this glass were done by using FTIR, FESEM, EDX and XRD respectively. The bioactive nature of the sample was analyzed by immersion in Phosphate Buffer Saline (PBS) for a period of 7 days and characte...

Potassium channel tetramerization domain containing 1 (KCTD1) family members have a BTB/POZ domain, which can facilitate protein-protein interactions involved in the regulation of different signaling pathways. KCTD proteins have potential Zn(2+)/Cu(2+) binding sites with currently unknown structural and functional roles. We investigated potential Cu(2+)-specific effects on KCTD1 using circular ...