Copper(II)  complex  [Cu(dmbt)2(H2O)](ClO4)2 (1)  was  prepared  from  the  reaction  of  copper(II) perchlorate  hexahydrate  with  2,2'-dimethyl-4,4'-bithiazole  (dmbt)  ligand  in  methanol  at  ambient temperature. The complex was quantitatively and qualitatively characterized by elemental analysis, absorption  and  infrared  spectrometries.  Complex  [Cu(DMSO)5](ClO4)2 (2)  was  also  synt...

The bleomycins (BLMs) are a family of natural glycopeptides used clinically as antitumor agents. In the presence of required cofactors (Fe(2+) and O(2)), BLM causes both single-stranded (ss) and double-stranded (ds) DNA damage with the latter thought to be the major source of cytotoxicity. Previous biochemical and structural studies have demonstrated that BLM can mediate ss cleavage through mul...

Sir: The oxidation of bleomycin (BLM)-Fe-DNA complex by molecular oxygen leads to damage of DNA.'," This activity is related to the bifunctionality of BLM, namely DNAand iron-binding. The bithiazole and terminal amine residues contribute toward the binding to DNA3,4) and the pyrimidoblamyl-(-hydroxyhistidyl portion (the amino acid residue containing pyrimidine is called pyrimidoblamic acid) is ...

M icrobes employ several catalytic strategies to transform conformationally f lexible peptide chains into rigidified scaffolds that possess antibiotic or toxin activity. Prominent examples include the biosynthesis of the -lactam antibiotics of the penicillin and cephalosporin families (1) and the maturation of vancomycin (2) where distinct structural modifications to the nascent peptide chains ...

Polymer solar cells (PSCs) have attracted much attention because of their potential application in flexible, light-weight, and low-cost large-area devices through roll-to-roll printing. The bulk heterojunction PSCs showed advanced features in realizing high efficiencies and solution-processible devices. The active layer in this kind of device consists of an interpenetrating network formed by an...