BACKGROUND Gold nanoparticles (AuNP) are extensively used as biophysical tools in the area of medicine and technology due to their distinct properties. However, vivid understanding of the consequences of biomolecule-nanomaterial interactions is still lacking. In this context, we explore the affect of conjugation of Gαi1 subunit (of heterotrimeric G-proteins) to AuNP and examine its consequences...

Field-effect transistors made from MoS2 and other emerging layered semiconductors have been demonstrated to be able to serve as ultrasensitive biosensors. However, such nanoelectronic sensors still suffer seriously from a series of challenges associated with the poor compatibility between electronic structures and liquid analytes. These challenges hinder the practical biosensing applications th...

This work highlights the rational design of recognitive networks via polymerization reaction analysis and detailed kinetic analysis for application in novel diagnostic or robust point-of-care devices. Non-covalent complexation interactions between template or ‘guest' biomolecules and functional monomers during polymerization can create networks with selective binding sites for biomolecules with...

Endogenous oxygen- and nitrogen-centered free radicals are considered to play a decisive role in a variety of diseases such as neurodegenerative disorders, atherosclerosis, or cancer. Directly operating antioxidants limit the action of freely diffusing radicals by scavenging the attacking, oxidizing radical and re-reducing the oxidized biomolecule, i.e., the biomolecule-derived radical. From te...

There has been a lot of discussion about biological water recently. Books 1-2 and reviews 3-5 were written in the past years and a special issue of the Journal of Chemical Physics was dedicated to the topic in 2014. 6 Interestingly, papers on biological water are mostly confined to chemistry and physics journals, being remarkably rare in biological or biochemical literature. So, what is actuall...