background beta catenin plays a key role in cancer tumorigenesis. however, its prognostic significance in patients with colorectal cancer (crc) remains controversial. it has been demonstrated that 90% of all tumors have a mutation in individual components of multiple oncogenes in wnt/β-catenin pathway. accumulation of nuclear β-catenin in cytoplasm leads to uncontrolled cell proliferation. thus...

purpose to date, little is known about the effects of a reduced level of jumping exercise regimens on bone turnover markers and mass. this study investigates the effects of different jumping exercise regimens with varying exercise loads on serum bone turnover markers and bone mass in female rats. methods a total of 144 female rats aged 12 weeks, were divided into 12 groups as follows: no exerci...

conclusions cornus mas fruit extract effect may be due to including some antioxidant components, which caused membrane stabilizing and normalization of fluctuated biochemical profiles induced by ccl4 exposure. our results validated the traditional use of cornus mas in the treatment of liver disorders. results oral administration of cornus mas fruits extract to rats for 14 days provided a signif...

Objective: Acute chest pain is an important and frequently occurring symptom in patients. Chest pain is often a sign of ischemic heart disease. Chest pain due to suspected Acute Coronary Syndrome (ACS) is responsible for a large and ijncreasing number of hospital attendances and admissions. Current practice for suspected ACS involves troponin testing 10–12 hours after symptom o...

historically, biomarkers have been used in two major ways to maintain and improve better health status: first, for diagnostic purposes, and second, as specific targets to treat various diseases.   a new era in treatment and even cure for the some diseases using reprograming of somatic cells is about to be born. in this approach, scientists are successfully taking human skin cells (previously co...

Background: Diffuse large B-cell lymphoma (DLBCL) is an aggressive malignancy of mature B lymphocytes. It is known as a heterogeneous disease with variable therapeutic responses and alternative therapies. Morphological and immunophenotypical evaluation of the biopsy specimens can help diagnose DLBCL. Methods: In the current study, 44 patients were chosen from Shaheed Sadoghi Hospital (2010&nda...

Background: This study was aimed to evaluate the effects of physical exercise on bone mineral density (BMD), lean body mass (LBM) and bone biomarkers in children with acute lymphoblastic leukemia on chemotherapy. Methods: forty-six leukemic children were randomly assigned to two groups; exercise group (E) undergoing supervised mixed exercise program consisting of aerobic, resistance and flexib...

background: psoriasis is a chronic and inflammatory dermatologic disease. inflammatory biomarkers such as c-reactive protein (crp) and erythrocyte sedimentation rate (esr) are known as immediate and delayed inflammatory biomarkers, respectively. due to the fact that anti-inflammatory drugs such as infliximab are widely used in psoriasis treatment, the aim of this study was to evaluate esr, crp ...

acute chest pain is an important and frequently occurring symptom in patients. chest pain is often a sign of ischemic heart disease. chest pain due to suspected acute coronary syndrome (acs) is responsible for a large and increasing number of hospital attendances and admissions. current practice for suspected acs involves troponin testing 10–12 hours after symptom onset to diagnose myocardial i...

background: diffuse large b-cell lymphoma (dlbcl) is an aggressive malignancy of mature b lymphocytes. it is known as a heterogeneous disease with variable therapeutic responses and alternative therapies. morphological and immunophenotypical evaluation of the biopsy specimens can help diagnose dlbcl. methods: in the current study, 44 patients were chosen from shaheed sadoghi hospital (2010–2013...