Glioblastoma, the most common primary brain malignancy, is an exceptionally fatal cancer. Lack of suitable biomarkers and efficient treatment largely contribute to therapy failure. Cytoskeletal proteins are crucial in glioblastoma pathogenesis can potentially serve as therapeutic targets. Among them, GFAP, has gained attention potential diagnostic biomarker, while vimentin microtubules consider...

medicinal chemistry depends on many other disciplines ranging from organic chemistry andpharmacology to computational chemistry. typically medicinal chemists use the moststraightforward ways to prepare compounds. the validation of any design project comes from thebiological testing.studies of the binding site of vinblastine by a single cross—linking experiment identified it asbeing between resi...

The irregularity of growing and shortening patterns observed experimentally in microtubules their ensembles reflects a dynamical system that fluctuates stochastically between assembly disassembly phases. time series microtubule lengths have been extensively analyzed to shed light on structural properties microtubules. Here, for the first time, Multifractal Detrended Fluctuation analysis (MFDFA)...

In this paper, we use the modified exp−ψθ-function method to observe some of solitary wave solutions for microtubules (MTs). By treating issues as nonlinear model partial differential equations describing microtubules, were able solve problem. We then found specific evolution equation (NLEE) covering various parameters that are particularly significant in biophysics and nanobiosciences. additio...

Cell stiffening induced by anticancer microtubule targeting drugs (MTDs) such as vinflunine (VFL), colchicine (COL), and docetaxel (DTX) can be driven crosstalk between actin filaments microtubules.

During neurite initiation, cells surrounded by a flattened, actin-rich lamellipodium transform to produce thin, microtubule-filled neurite shafts tipped by actin-rich growth cones, but little is known about this transformation. Our detailed time-lapse analyses of cultured hippocampal neurons, a widely used model system for neuronal development, revealed that neurites emerge from segmented lamel...