The size of affibody molecules makes them suitable as targeting agents for targeted radiotherapy with the alpha-emitter 211At, since their biokinetic properties match the short physical half-live of 211At. In this study, the potential for this approach was investigated in vivo. Two different HER-2 binding affibody molecules were radiolabeled with 211At using both the linker PAB (N-succinimidyl-...

The Constructed Wetland Model No. 1 (CWM1) is a biokinetic model describing microbial dynamics and transformation and degradation processes in subsurface flow constructed wetlands. The implementation of CWM1 in the HYDRUS program package (©PC Progress s.r.o.) was verified using data from controlled environment column experiments. These 20-day long batch experiments used synthetic wastewater and...

A biokinetic model of the systemic distribution of americium in the beagle dog is presented. The model is based on a previous biokinetic model of plutonium. The data sets used for the development of the model are the measurements of excreted activity (urine and feces) and organ burdens (skeleton, liver and other soft tissues). In developing the model, the part of the plutonium model representin...

A pilot study was conducted for the U.S. Nuclear Regulatory Agency (NRC) to examine the feasibility of characterizing and improving the reliability of current dose coefficients for a comprehensive set of radionuclides of concern to the NRC. The dose coefficients considered for inhalation and ingestion were those currently recommended by the International Commission on Radiological Protection (I...

The objective of this manuscript is to provide a description of the International Commission for Radiation Protection (ICRP) model and a comparison to other models (the integrated exposure uptake biokinetic [IEUBK] and O'Flaherty models), including the software used with the models, and a comparison of the model predictions for selected situations. The ICRP biokinetic model for Pb is a multicom...

The integrated exposure uptake biokinetic model for lead in children was developed to provide plausible blood lead distributions corresponding to particular combinations of multimedia lead exposure. The model is based on a set of equations that convert lead exposure (expressed as micrograms per day) to blood lead concentration (expressed as micrograms per deciliter) by quantitatively mimicking ...

Dose reconstruction is a comprehensive analysis of the exposure received by individuals in the vicinity of facilities that release contaminants to the environment (i.e., real doses to real people).Performing dose reconstruction analyses which are extremely important elements for improving efficiency in radiological emergencies and accidents have been studied in this paper. For dose reconstructi...