نتایج جستجو برای: bioconjugation
تعداد نتایج: 645 فیلتر نتایج به سال:
Bromopyridazinedione-mediated bioconjugation to a cysteine containing protein and a disulfide containing peptide is described. The conjugates are cleavable in an excess of thiol, including cytoplasmically-relevant concentrations of glutathione, and show a high level of hydrolytic stability. The constructs have the potential for four points of chemical attachment.
Targeted metallic nanoparticles have shown promise as contrast agents for molecular imaging. To obtain molecular specificity, the nanoparticle surface must be appropriately functionalized with probe molecules that will bind to biomarkers of interest. The aim of this study was to develop and characterize a flexible approach to generate molecular imaging agents based on gold nanoparticles conjuga...
Wang, S. 2017. Insights into dynamic covalent chemistry for bioconjugation applications. Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Science and Technology 1554. 59 pp. Uppsala: Acta Universitatis Upsaliensis. ISBN 978-91-513-0065-8. Dynamic covalent chemistry (DCC) is currently exploited in several areas of biomedical applications such as in drug discovery, sen...
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