Background: Quantifying the robustness of biochemical models is important both for determining the validity of a natural system model and for designing reliable and robust synthetic biochemical networks. Several tools have been proposed in the literature. Unfortunately, multiparameter robustness analysis suffers from computational limitations. Results: A novel method for quantifying the robustn...

Nonlinearities and the lack of accurate quantitative information considerably hamper modeling and system analysis of biochemical networks. Here we propose a procedure for qualitative mathematical analysis of piecewise-affine (PWA) approximations of these networks. First the biochemical model size was reduced with quasi-steady state approaches by taking a priori information into account. Second,...

This paper proposes a minimal model of a biochemical reaction pathway involving coupled negative and positive feedback mechanisms that are common in cellular processes. The analytical and numerical studies show that this pathway is capable of eliciting a large variety of functional dynamics at different parameter values. Keywords— Biochemical reactions, Feedback, Hopf bifurcation, perioddoublin...

Sixty patients of pleural effusion with different aetiology are described. Various microbiological and biochemical parameters were done simultaneously in blood and pleural fluid to differentiate tuberculosis and non-tuberculosis effusions. Some biochemical tests were thought to be helpful in differential diagnosis but no single parameter was found diagnostic. Routine investigations of pleural f...

Computational modeling and simulation of biochemical networks is at the core of systems biology and this includes many types of analyses that can aid understanding of how these systems work. COPASI is a generic software package for modeling and simulation of biochemical networks which provides many of these analyses in convenient ways that do not require the user to program or to have deep know...

Nowadays, numerical models have great importance in every field of science, especially for solving the nonlinear differential equations, partial differential equations, biochemical reactions, etc. The total time evolution of the reactant concentrations in the basic enzyme-substrate reaction is simulated by the Runge-Kutta of order four (RK4) and by nonstandard finite difference (NSFD) method. A...