نتایج جستجو برای: biochemical mechanism
تعداد نتایج: 687990 فیلتر نتایج به سال:
The mechanism(s) underlying contractile dysfunction in cardiac stunning is not completely understood. The expression and/or the phosphorylation state of cardiac Ca(2+) homoeostasis-regulating proteins might be altered in stunning. We tested this hypothesis in a well-characterized model of stunning. Conscious dogs were chronically instrumented, and the left anterior descending artery (LAD) was o...
resistance to 6-thioguanine (6-TG) of some cell lines resistant to 6-mercaptopurine (6-MP) have led some investigators to assume that 6-TG and 6-MP havesimilar or identicalmetaboliceffects. This cross-resistance can probably be explained on the basis of the resistance mechanism, which has been so thoroughly investigated by Brock man and his associates (2). Since it now ap pears that both 6-MP a...
s 2010 283
Biochemical mechanisms of production of redox intermediates of redox-cycling drugs include: photochemical events, either photoionization process or electron transfer from photoexcited states; electron exchange of reduced form of a drug with the oxy state of oxygen-binding hemoproteins; oxidation by catalytic metal centers (oxidases, peroxidases, oxygenases) of the reduced forms of drugs; or ele...
The human APOBEC3 (A3) family (A, B, C, DE, F, G, and H) comprises host defense factors that potently inhibit the replication of diverse retroviruses, retrotransposons, and the other viral pathogens. HIV-1 has a counterstrategy that includes expressing the Vif protein to abrogate A3 antiviral function. Without Vif, A3 proteins, particularly APOBEC3G (A3G) and APOBEC3F (A3F), inhibit HIV-1 repli...
systems (3—5,12, 13, 17, 18) have led to the hypothesis that the active form of 6-MP is its ribonucleotide (thio inosinate, 6-thio IMP), which inhibits the further conver sion by inosinate to other purine ribonucleotides (4, 5). This inhibition by thioinosinate of the formation of ade nylate and guanylate has been demonstrated in cell-free preparations from Streptococcus faecalis and pigeon l...
Natural fragmentation of polypeptide chains by autoproteolysis occurs in a number of protein families. It is a vital step in the maturation of several enzymes and in the formation of membraneassociated mucins that constitute a part of the protective mucus barrier lining epithelial cells. These reactions follow similar routes involving an initial N→O or N→S acyl shift starting with a nucleophili...
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