Protein-DNA interactions are required for access and protection of the genetic information within the cell. Historically these interactions have been studied using genetic, biochemical, and structural methods resulting in qualitative or semiquantitative interaction data. In the future the focus will be on high quality quantitative data to model a huge number of interactions forming a specific n...

Francisco Mauro Salzano, Fabrício Rodrigues dos Santos, Klaus Hartfelder, Carlos F.M. Menck Departamento de Genética, Instituto de Biociências, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil. Departamento de Biologia Geral, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil. Departamento de Biologia Celular e Molecular e Bioag...

HE biochemical genetics of carotenoid pigments has been studied in the T tomato ( LEROSEN et al. 1941 ; MACKINNEY and JENKINS 1949 ; PORTER and LINCOLN 1950), corn (MANGELSDORF and FRAPS 1931) and red yeast (BONNER et al. 1946). HAXO (1949) worked out the carotenoid components of the wild type Neurospora. The present paper deals with genetic and biochemical studies of a modifier system for pigm...

SEVENTY-FIVE years ago, George Beadle and Edward Tatum published their method for producing nutritional mutants inNeurospora crassa. Their study signaled the start of a new era in experimental biology, but its significance is generally misunderstood today. The importance of the work is usually summarized as providing support for the “one gene– one enzyme” hypothesis, but its major value actuall...

A total of 1,628 papers presented at the sixth and seventh World Congresses on Genetics Applied to Livestock Production were categorized into 20 topics according to research subjects. The aim was to determine, in relation to various topics in animal breeding and genetics, the forms of partnerships and the degree of attention given in different continents. North-North partnerships (defined as co...

We present the design of an object-oriented database system for reverse genetics applications. Such a database will encapsulate not only the data in the genetic and physical maps, but also the methods used to create the maps as well as methods to link them to other databases, such as GenBank, PIR, and MedLine. The purpose of this database is to provide the fungal genetics community with an elec...

This article is an editor's introduction to the theme of an issue of the Schizophrenia Bulletin devoted to subgroups of the schizophrenic syndrome. The issue includes articles on subtyping from various points of view: neurological, genetic, biochemical, and descriptive. It is hoped that the wide range of findings being applied in ongoing classificatory efforts will produce subgroups with etiolo...

The SH3 domain is perhaps the best-characterized member of the growing family of protein-interaction modules. By binding with moderate affinity and selectivity to proline-rich ligands, these domains play critical roles in a wide variety of biological processes ranging from regulation of enzymes by intramolecular interactions, increasing the local concentration or altering the subcellular locali...

A combination of classical genetic, biochemical, and molecular biological approaches have generated a rather detailed understanding of the structure and function of Saccharomyces telomeres. Yeast telomeres are essential to allow the cell to distinguish intact from broken chromosomes, to protect the end of the chromosome from degradation, and to facilitate the replication of the very end of the ...