the cytotoxicity of the biomaterials is a key issue that should be addressed prior to pre-clinical applications. this study was designed to evaluate and compare the cytotoxixity of two forms of bioactive glasses:nanopowder:andmicropowder. human hgf1-pi53 gingival fibroblast cells were used to evaluate the cytotoxicity of 0.5, 1, 1.5, 2, 5, 10, 15 and 20 mg/ml concentrations of the two bioactive...

Bioactive glasses are known to stimulate bone healing, and the incorporation of strontium has the potential to increase their potency. In this study, calcium oxide in the 45S5 bioactive glass composition was partially (50%, Sr50) or fully (100%, Sr100) substituted with strontium oxide on a molar basis. The effects of the substitution on bioactive glass properties were studied, including density...

Bone defects caused by trauma or pathological events are major clinical and socioeconomic burdens. Thus, the efforts of regenerative medicine have been focused on the development of non-biodegradable materials resembling bone features. Consequently, the use of bioactive glass as a promising alternative to inert graft materials has been proposed. Bioactive glass is a synthetic silica-based mater...

BACKGROUND Mastoid obliteration seeks to replace an open mastoid cavity with material that will become viable and free of infection and cholesteatoma. The purpose of this study was to evaluate the efficacy of bioactive glass ceramic particles for mastoid obliteration using a guinea pig animal model. MATERIALS AND METHODS Ten male guinea pigs (weighing 250-300 g) with normal eardrums and Preye...

Nanoscale bioactive glasses have been gaining attention due to their superior osteoconductivity when compared to conventional (micron-sized) bioactive glass materials. The combination of bioactive glass nanoparticles or nanofibers with polymeric systems enables the production of nanocomposites with potential to be used in a series of orthopedic applications, including tissue engineering and reg...

INTRODUCTION This study aimed to evaluate the potential applications of polycaprolactone (PCL)/submicron bioactive glass (smBG) hybrid composites for pulp and dentin tissue regeneration. METHODS PCL/smBG hybrid composites were made with novel monodispersive bioactive glass submicrospheres, and pure PCL and bioactive glass samples were used as controls. Surface characteristics were assessed by...

Responses of mesenchymal stem cells (MSCs) cultured with zinc-added (2 and 5%) bioactive glass granules were evaluated in terms of cell growth and osteogenic differentiation. MSCs were cultured with different quantities (3, 10 and 30) of glass granules for up to 21 days in the osteogenic medium. Cell growth was stimulated by a small quantity of glasses, particularly those that contained zinc. O...

In this paper synthesis and characterization of a bioactive calcium phosphate glass-ceramic is presented, synthesized using a facile method. The glass-ceramic samples are synthesized with heat treating the parent glass at appropriate temperatures, where different calcium phosphate crystalline phases are grown in the parent glass samples during the heat treatment. The amounts of elements a...