Introduction Glucokinase (hexokinase D) is an enzyme that phosphorylates glucose in hepatocytes totrap it in the cell and prime it for conversion to other compounds, yet this enzyme has low affinity to bind with glucose. In Diabetes Mellituspatients, the blood glucose level is poorly controled. Material and Methods This study explored the possibility to induce glucokinase activity with bioact...

Objectives: The purpose of this study was to analyze and evaluate evidence supporting curcumin lowering the systemic inflammatory marker, CRP in humans. Methods: A systematic literature search completed using PubMed MEDLINE databases. Results: After inclusion exclusion criteria, 9 studies were evaluated, percent change blood levels calculated analyzed. results for these show strong statistical ...

The main aim of this research was to find the mechanism for the failure of the CoCrMo porous nano-composite by characterizing microstructural changes and fractured surface after compression test. For this purpose, porous nano-composites were prepared with the addition of bioactive glass nano-powder to Co-base alloy with 22.5% porosity by the combination of space-holder and powder metallurgy tec...

CuO, Fe2O3, MnO2 and ZnO substituted 45S5 bioactive glasses were prepared. Glass derived Bioactive Glass ceramics were obtained through controlled crystallization of bioactive glasses. The formed crystalline phases in bioactive glass ceramics were identified using X ray diffraction (XRD) analysis. Density and ultrasonic wave velocities of bioactive glasses and glass ceramics were measured and u...

background: the greater surface of bioactive glass nanoparticles presents an incomparable and promising feature similar to the biological apatite. nanoparticles improve cellular adhesion, enhance osteoblast proliferation and differentiation, and increase biomineralization for periodontal regeneration and dental implants. considering the fact that interaction between periodontal cells and bone g...

OBJECTIVES To investigate the long term association of subthalamic beta activity with parkinsonian motor signs. METHODS We recruited 15 patients with Parkinson's disease undergoing subthalamic DBS for local field potential recordings after electrode implantation, and at 3 and 8months post-operatively using the implantable sensing enabled Activa PC+S (Medtronic). Three patients dropped out lea...

The HKR of racemic syn- or anti- alkoxy- and azido epoxides catalyzed by Co(salen) complex affords a practical access to a series of enantioenriched syn- or anti- alkoxy- and azido epoxides and the corresponding 1,2-diols. This strategy has been successfully employed in the concise, enantioselective synthesis of bioactive molecules such as (S,S)-reboxetine and (+)-epi-cytoxazone.

Sesterterpenoids account for many bioactive natural products, often with unusual and complex structural features, which makes them attractive targets for synthetic chemists. This review surveys efforts undertaken toward the synthesis of sesterterpenoids, focusing on completed total syntheses and covering ca. 50 natural products in total.

The complex [PtCl 2 (cyclohexane-1 R ,2 -diamine)] has been combined in a Pt(IV) molecule with two different bioactive molecules (i.e., the histone deacetylase inhibitor 2-propylpentanoic acid or valproic acid, VPA , and potential antimetastatic...